Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Guinea Pig,
适应物种:
Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Guinea Pig,
免疫原:
详见说明书
亚型:
IGg
形态:
粉末、液体、冻干粉
应用范围:
IF=1:50-200
浓度:
1mg/ml
保存条件:
-20 °C
规格:
100ul
FITC标记的磷酸化多巴胺/cAMP调节神经磷蛋白抗体
英文名称
Anti-Phospho-DARPP32 (Thr34)/FITC
中文名称
FITC标记的磷酸化多巴胺/cAMP调节神经磷蛋白抗体
别 名
DARPP32 (phospho T34); p-DARPP32 (phospho T34); Ppp1r1b(phospho T34); DARPP 32; Dopamine and cAMP regulated neuronal phosphoprotein; Dopamine and cAMP regulated phosphoprotein DARPP 32; Dopamine and cAMP regulated phosphoprotein DARPP32; FLJ20940; IPPD; Neuronal phosphoprotein DARPP 32; PPP1R1B; Protein phosphatase 1 regulatory (inhibitor) subunit 1B; Protein phosphatase 1 regulatory subunit 1B; PPR1B_HUMAN.
规格价格
100ul/2980元 购买 大包装/询价
说 明 书
100ul
产品类型
磷酸化抗体
研究领域
免疫学 神经生物学
抗体来源
Rabbit
克隆类型
Polyclonal
交叉反应
Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Guinea Pig,
产品应用
IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分 子 量
32kDa
性 状
Lyophilized or Liquid
浓 度
1mg/ml
免 疫 原
KLH conjugated Synthesised phosphopeptide derived from human DARPP32 around the phosphorylation site of Thr34
亚 型
IgG
纯化方法
affinity purified by Protein A
储 存 液
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍
background: This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
Function: Inhibitor of protein-phosphatase 1.
Subcellular Location: Cytoplasm.
Post-translational modifications: Phosphorylation of Thr-34 is required for activity.
Similarity: Belongs to the protein phosphatase inhibitor 1 family.
Database links:
Entrez Gene: 84152 Human
Entrez Gene: 19049 Mouse
Entrez Gene: 360616 Rat
Omim: 604399 Human
SwissProt: Q9UD71 Human
SwissProt: Q60829 Mouse
SwissProt: Q6J4I0 Rat
Unigene: 286192 Human
Unigene: 45372 Mouse
Unigene: 70366 Rat
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
DARPP-32通过自身不同位点的磷酸化对蛋白质磷酸化和去磷酸化过程发挥着双向调控的作用.DARRP-32在脑内存在于接受多巴胺能投射的神经元中,其磷酸化过程受多种神经递质的调控,在信号转导途径中处于中心位置,整合多种胞内信号转导,调节神经元的电学和化学性质以及动物的生理行为反应,参与多种生理功能和病理过程,包括药物成瘾、抑郁症、精神分裂症等.此外,DARPP-32在非神经系统的功能也逐渐被人们所认识. 多巴胺和cAMP调节的磷蛋白(dopamine and adenosine 3'5'-monophosphate-regulated phospho-protein,Mr 32 kD,DARPP-32)是一个具有双重功能的独特蛋白,它既是磷酸酶(如PP-1)的抑制剂,也是蛋白激酶(如PKA)的抑制剂。