Product overview
Description Anti-HK1 rabbit polyclonal antibody
Applications ELISA, WB, IHC
Immunogen Fusion protein of human HK1
Reactivity Human, Mouse, Rat
Content 0.5 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol HK1
Full name hexokinase 1
Synonyms HKD; HKI; HXK1; HMSNR; HK1-ta; HK1-tb; HK1-tc
Swissprot P19367
Target Background
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus; the remainder of the protein is identical among all the isoforms.