LS-F16083 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat FKBP38 / FKBP8. It is based upon a Custom assay principle.
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Specifications
Type
Custom ELISA kit
All LSBio Custom kits have been predesigned and all necessary components, including antibodies and standards have been identified. Upon receiving a custom kit order, the kit will be assembled and quality control tested before being shipped out. Kit assembly and testing typically takes 4 to 6 weeks. In most cases the final kit is based on the Sandwich assay principle, with a few being Competitive EIA based. Specifications such as Range, Sensitivity, and Precision are defined upon completion. In the event that the custom kit cannot be successfully developed with 6 weeks of the order date, the customer will be notified and the order canceled at no cost.
Target
FKBP38 / FKBP8
Synonyms
FKBP8, 38 kDa FKBP, 38 kDa FK506-binding protein, FKBP-8, FK506-binding protein 8, FKBP38, HFKBP38, FKBP-38, Rotamase, FK506 binding protein 8, 38kDa, FK506-binding protein 8 (38kD), FKBPr38, PPIase FKBP8
Reactivity
Rat
Manual
Format
96-Well Strip Plate
Detection
Colorimetric - 450nm (TMB)
Measurement
Quantitative
Detection Range
To be determined
Sensitivity
To be determined
Storage
Short term: 4°C; Long term: see manual.
Kit Components
Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. Q14318NM_012181NP_036313.3