Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit,
产品应用
IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分 子 量
66kDa
性 状
Lyophilized or Liquid
浓 度
1mg/ml
免 疫 原
KLH conjugated Synthesised phosphopeptide derived from human Nur77 around the phosphorylation site of Ser351
亚 型
IgG
纯化方法
affinity purified by Protein A
储 存 液
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍
background: This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Function: Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2.
Subunit: Binds DNA as a monomer. Interacts with GADD45GIP1.
Subcellular Location: Nucleus.
Tissue Specificity: Fetal muscle and adult liver, brain and thyroid.
Post-translational modifications: Phosphorylated at Ser-351 by RPS6KA1 and RPS6KA3 in response to mitogenic or stress stimuli.
Similarity: Belongs to the nuclear hormone receptor family. NR4 subfamily. Contains 1 nuclear receptor DNA-binding domain.
Database links:
Entrez Gene: 3164 Human
Entrez Gene: 15370 Mouse
Entrez Gene: 79240 Rat
Omim: 139139 Human
SwissProt: P22736 Human
SwissProt: P12813 Mouse
SwissProt: P22829 Rat
Unigene: 524430 Human
Unigene: 119 Mouse
Unigene: 10000 Rat
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.