Product overview
Description Anti-TNF rabbit polyclonal antibody
Applications ELISA, WB, IHC
Immunogen Synthetic peptide of human TNF
Reactivity Human, Mouse
Content 1.32 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol TNF
Full name tumor necrosis factor
Synonyms DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha
Swissprot P01375
Target Background
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.