Product overview
Description Anti-NFATC1 rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Fusion protein of human NFATC1
Reactivity Human, Mouse
Content 0.2 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol NFATC1
Full name nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
Synonyms NFAT2, NFATc, NF-ATC
Swissprot O95644
Target Background
The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.