Soluble in DMF(* 建议使用 DMF 而不是 DMSO溶解。* 该产品在溶液状态不稳定,建议您现用现配/*Use DMF instead of DMSO to dissolve.*The product is unstable after dissolution. It is recommended that you use it immediately after dissolution.)
EC
EINECS 239-733-8
MDL
MFCD00011623
InChIKey
DQLATGHUWYMOKM-UHFFFAOYSA-L
InChI
InChI=1S/2ClH.2H2N.Pt/h2*1H;2*1H2;/q;;2*-1;+4/p-2
PubChem CID
2767
SMILES
[Cl-][Pt+2]([Cl-])([NH3])[NH3]
描述
Cisplatin与 DNA 交联引起癌细胞中 DNA 损伤,可用于抗肿瘤化疗药物方向的研究。Cisplatin可激活铁死亡 (ferroptosis) 并诱导自噬 (autophagy)。(Cisplatin cross-linking with DNA can cause DNA damage in cancer cells and can be used in the research of anti-tumor chemotherapy drugs. Cisplatin can activate ferroptosis and induce autophagy.)
[1]. Wang X, et al. Requirement for ERK activation in cisplatin-induced apoptosis. J Biol Chem. 2000 Dec 15;275(50):39435-43. [2]. Cummings BS, et al. Cisplatin-induced renal cell apoptosis: caspase 3-dependent and -independent pathways. J Pharmacol Exp Ther. 2002 Jul;302(1):8-17. [3]. Park HR, et al. Enhanced antitumor efficacy of cisplatin in combination with HemoHIM in tumor-bearing mice. BMC Cancer. 2009 Mar 17;9:85. [4]. Shimeda Y, et al. Protective effects of capsaicin against cisplatin-induced nephrotoxicity in rats. Biol Pharm Bull. 2005 Sep;28(9):1635-8.