KRN2,1390654-28-0

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KRN2 bromide

CAS No. : 1390654-28-0

MCE 国际站：KRN2 bromide

产品活性：KRN2 bromide 是选择性的 T 细胞激活核因子 (NFAT5) 的抑制剂，IC₅₀ 值为 100 nM。KRN2 bromide 有潜力用于 NFAT5-介导的慢性关节炎的潜能。

研究领域：Immunology/Inflammation

作用靶点：Nuclear Factor of activated T Cells (NFAT)

In Vitro: KRN2 selectively suppresses the expression of pro-inflammatory genes, including Nos2 and Il6, without hampering high-salt-induced NFAT5 and its target gene expressions.
KRN2 dose-dependently inhibits the NF-κB p65 binding to Nfat5 promoter 1 and directly blocks the interaction between NF-κB p65 and its DNA binding sequence in the upstream site (base pairs -3000 to +1) of Nfat5 exon 1.

In Vivo: KRN2 (3 mg/kg, i.p., daily for 2 weeks) effectively suppresses AIA in which innate immune cells play a predominant role.
KRN2 (3 mg/kg, i.p., daily) effectively suppresses CIA as well as AIA in mice, decreasing the production of pro-inflammatory cytokines and autoantibodies as well as macrophage infiltration.

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