Pyr3,1160514-60-2

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Pyr3

CAS No. : 1160514-60-2

MCE 国际站：Pyr3

产品活性：Pyr3 是 TRPC3 的选择性抑制剂，其对 TRPC3 介导的 Ca²⁺ 内流的 IC₅₀ 值为 700 nM。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：TRP Channel

In Vitro: Pyr3 selectively and directly inhibits TRPC3 channels among TRPC family members. Application of Pyr3 inhibits TRPC3-mediated Ca²⁺ influx in a dose-dependent manner with the IC₅₀ value of 700 nM. Pyr3 becomes apparent at 0.3 μM, and is almost complete at 3 μM. Interestingly, Ca²⁺ influx is inhibited by Pyr3 in cells co-expressing TRPC3 plus TRPC6 but not in cells coexpressing TRPC1 plus TRPC5. The Ang II-induced NFAT translocation is suppressed by Pyr3, but weakly by Pyr2 in a concentration-dependent manner (IC₅₀ value was 0.05 μM for Pyr3 and 2 μM for Pyr2).

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