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- 详细信息
- 文献和实验
- 技术资料
- 库存：
大量
- 英文名：
Metronidazole
- CAS号：
443-48-1
- 保质期：
2年
- 供应商：
上海瓦兰生物
- 保存条件：
2-8℃
- 规格：
5G
性质
| Related Categories | Antibacterial, Antibiotics A to Z, Antibiotics G-M,Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, 更多... |
| InChI Key | VAOCPAMSLUNLGC-UHFFFAOYSA |
| product line | BioXtra |
| impurities | ≤0.0005% Phosphorus (P) |
| ≤0.1% Insoluble matter | |
| ign. residue | ≤0.1% |
| color | white to light yellow |
| mp | 159-161 °C(lit.) |
| solubility | acetic acid: 0.1 M, clear, colorless to yellow |
| anion traces | chloride (Cl-): ≤0.05% |
| sulfate (SO42-): ≤0.05% | |
| cation traces | Al: ≤0.0005% |
| Ca: ≤0.005% | |
| Cu: ≤0.0005% | |
| Fe: ≤0.0005% | |
| K: ≤0.005% | |
| Mg: ≤0.0005% | |
| Na: ≤0.01% | |
| Pb: ≤0.001% | |
| Zn: ≤0.0005% | |
| Mode of action | DNA synthesis | interferes |
| antibiotic activity spectrum | Gram-negative bacteria |
| parasites | |
| storage temp. | 2-8°C |
产品描述
包装
5, 25 g in glass bottle
Application
Metronidazole is a nitroimidazole used to treat amebiasis, vaginitis, Trichomonas infections, giardiasis, anaerobic bacteria and treponemal infections. Metronidazole is used to study DNA damage and repair and has been found to induce the gene transfer agent VSH-1 in Brachyspira hyodysenteriae. It is commonly used for treatment of periodontitis and is used in bioavailability studies.
Biochem/physiol Actions
Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce metronidazole to its active form. Reduced metronidazole covalently binds to DNA which disrupts its helical structure, induces DNA strand breaks and inhibits bacterial nucleic acid synthesis. Bacterial cell death results.
General description
Chemical structure: imidazole
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技术资料