IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分 子 量
56kDa
性 状
Lyophilized or Liquid
浓 度
1mg/ml
免 疫 原
KLH conjugated synthetic peptide derived from human IMPDH2
亚 型
IgG
纯化方法
affinity purified by Protein A
储 存 液
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍
background: Rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some tumors.
Function: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
Subunit: Homotetramer.
Subcellular Location: Cytoplasm. Nucleus.
Tissue Specificity: IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor.
Post-translational modifications: The N-terminus is blocked.
Similarity: Belongs to the IMPDH/GMPR family. Contains 2 CBS domains.
Database links:
Entrez Gene: 3615 Human
Entrez Gene: 23918 Mouse
Entrez Gene: 301005 Rat
Omim: 146691 Human
SwissProt: P12268 Human
SwissProt: P24547 Mouse
SwissProt: E9PU28 Rat
Unigene: 654400 Human
Unigene: 6065 Mouse
Unigene: 8093 Rat
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.