AS 8351组蛋白去甲基化酶抑制剂

AS 8351组蛋白去甲基化酶抑制剂

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  • ¥1400
  • Biogems
  • 7964296-10mg
  • 2025年07月16日
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      10mg

    AS 8351组蛋白去甲基化酶抑制剂
    Catalog Number : 7964296

    Description

    AS 8351 is an iron chelator and histone demethylase inhibitor, targeting KDM5B (JARID1B). It is reported to efficiently induce cardiac reprogramming of human fibroblasts in conjunction with other small molecules. KDM5B is a multi-domain demethylase enzyme that is overexpressed in many cancer types.
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    Additional Information

    Applications
    FA
    Synonyms:
    AS8351, AS-8351, NSC-51355, 2-Hydroxy-1-naphthylaldehyde isonicotinoylhydrazone
    Formulation:
    Crystalline solid
    Chemical Name:
    N'-[(Z)-(2-oxonaphthalen-1-ylidene)methyl]pyridine-4-carbohydrazide
    Molecular Formula:

    C17H13N3O2

    Molecular Weight:
    291.3
    CAS Number
    796-42-9
    Purity:
    ≥98%
    Storage Conditions:
    Product should be kept at -20°C.
    References:

    Cao, N., Huang, Y., Zheng, J., Spencer, C. I., Zhang, Y., Fu, J. D., ... & Ma, T. (2016). Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science352(6290), 1216-1220.

    Chen, Y., Yang, Z., Zhao, Z. A., & Shen, Z. (2017). Direct reprogramming of fibroblasts into cardiomyocytes. Stem cell research & therapy8(1), 118.

    Hayami, S., Yoshimatsu, M., Veerakumarasivam, A., Unoki, M., Iwai, Y., Tsunoda, T., ... & Ponder, B. A. (2010). Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway. Molecular cancer9(1), 59.

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