Associated molecule with the SH3 domain of STAM; Endosome associated ubiquitin isopeptidase; Endosome-associated ubiquitin isopeptidase; STABP_HUMAN; STAM binding protein; STAM-binding protein; STAMBP.
规格价格
100ul/2980元 购买 大包装/询价
说 明 书
100ul
研究领域
细胞生物 细胞周期蛋白 结合蛋白 表观遗传学
抗体来源
Rabbit
克隆类型
Polyclonal
交叉反应
Human, Mouse, Rat, Dog, Horse, Rabbit,
产品应用
IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分 子 量
47kDa
细胞定位
细胞膜
性 状
Lyophilized or Liquid
浓 度
1mg/ml
免 疫 原
KLH conjugated synthetic peptide derived from human AMSH
亚 型
IgG
纯化方法
affinity purified by Protein A
储 存 液
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍
background: Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Functions at the endosome and is able to oppose the ubiquitin-dependent sorting of receptors to lysosomes. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7.
Function: Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Functions at the endosome and is able to oppose the ubiquitin-dependent sorting of receptors to lysosomes. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7.
Subcellular Location: Nucleus. Membrane; Peripheral membrane protein. Cytoplasm. Early endosome.
Tissue Specificity: Ubiquitously expressed.
Post-translational modifications: Phosphorylated after BMP type I receptor activation. Ubiquitinated by SMURF2 in the presence of RNF11.
Similarity: Belongs to the peptidase M67C family. Contains 1 MPN (JAB/Mov34) domain.
Database links: Entrez Gene: 10617 Human Entrez Gene: 70527 Mouse Entrez Gene: 171565 Rat Omim: 606247 Human SwissProt: O95630 Human SwissProt: Q9CQ26 Mouse SwissProt: Q8R424 Rat Unigene: 469018 Human Unigene: 657598 Human Unigene: 32801 Mouse Unigene: 14662 Rat
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.