Fam3c; FAM3C_HUMAN; family with sequence similarity 3, member C; GS3786; ILEI; Interleukin-like EMT inducer; Predicted osteoblast protein; Protein FAM3C.
规格价格
100ul/2980元 购买 大包装/询价
说 明 书
100ul
研究领域
肿瘤 细胞生物 免疫学 细胞周期蛋白 细胞分化
抗体来源
Rabbit
克隆类型
Polyclonal
交叉反应
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse,
产品应用
IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分 子 量
22kDa
性 状
Lyophilized or Liquid
浓 度
1mg/ml
免 疫 原
KLH conjugated synthetic peptide derived from human FAM3C
亚 型
IgG
纯化方法
affinity purified by Protein A
储 存 液
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍
background: ILEI is a 227 amino acid, ubiquitously expressed protein containing an amino-terminal signal peptide. Elevated levels of ILEI translation are observed in oncogenic, Ras-transformed mammary epithelial cells and epithelial to mesenchymal transition (Emt) as well as tumor growth and metastasis. Also, overexpression of ILEI results in loss of ZO-1, a protein involved in tight junctions, and expression of cytoplasmic E-cadherin, which has been shown to influence loss of polarity and invasiveness. Due to this evidence, it is suspected that ILEI cooperates with oncogenic Ras to cause TGF∫-independent Emt and its overexpression is correlated with the invasion, metastasis and survival in a variety of cancers.
Function: May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition.
Subcellular Location: Secreted. Cytoplasmic vesicle. Note=Cytoplasmic in some cancer cells.
Tissue Specificity: Present in most secretory epithelia (at protein level).
Similarity: Belongs to the FAM3 family.
Database links:
UniProtKB/Swiss-Prot: Q92520.1
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.