- ¥1528
- abcam
- ab120111
- 美国
- 2025年12月30日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
1
- 英文名：
Ifenprodil hemitartrate
- CAS号：
23210-58-4
- 保质期：
1年
- 供应商：
艾博抗（上海）贸易有限公司
- 保存条件：
4℃ 冻干粉
- 规格：
50mg
概述
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产品名称Ifenprodil hemitartrate
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描述GluN2B (formerly NR2B)-preferring NMDA拮抗剂
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生物学描述Non-competitive NMDA receptor antagonist acting at the polyamine site. Displays GluN2B (formerly NR2B) subunit selectivity. IC50 values are 0.15 μM at NR1/NR2B and >30 μM for NR1/NR2A, NR1/NR2C and NR1/NR2D receptors.
Also available in simple stock solutions (ab146675) - add 1 ml of water to get an exact, ready-to-use concentration. -
纯度> 99%
性能
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化学名称erythro-4-(2-(4-Benzylpiperidin-1-yl)-1-hydroxypropyl)phenol hemitartrate
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分子量400.49
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化学结构
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分子式C21H27NO2.0.5C4H6O6
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CAS编号23210-58-4
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存放说明Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
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溶解度概述Soluble in water to 15 mM and in DMSO to 100 mM
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处理Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. -
来源Synthetic
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研究领域
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图片
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Functional Studies - Ifenprodil (ab120111)Image from Case DT et al., PLoS One. 2011;6(6):e20756. Fig 4(D).; doi: 10.1371/journal.pone.0020756.Median ifenprodil sensitivity from a rat postnatal day 2 (P2) and day 12 (P12) neuron; NMDAR-mediated responses in control (black) and in presence of the GluN2B-preferring antagonist ifenprodil (ab120111, grey).
文献
This product has been referenced in:
- Paoletti P & Neyton J NMDA receptor subunits: function and pharmacology. Curr Opin Pharmacol 7:39-47 (2007). Read more (PubMed: 17088105) »
- Williams K Ifenprodil, a novel NMDA receptor antagonist: site and mechanism of action. Curr Drug Targets 2:285-98 (2001). Read more (PubMed: 11554553) »
- Reynolds IJ & Miller RJ Ifenprodil is a novel type of N-methyl-D-aspartate receptor antagonist: interaction with polyamines. Mol Pharmacol 36:758-65 (1989). Read more (PubMed: 2555674) »
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文献和实验N -methyl-d -aspartate receptors (NMDARs) are ligand-gated ion channels belonging to the family of ionotropic glutamate receptors. Functional NMDARs are heterotetrameric assemblies of NR1 subunits with at least one type of NR2 subunits
Radioligand Binding Assays for the Glycine Site on N‐Methyl‐D‐Aspartate Receptors
, P.H. 2000. Characterisation of N‐methyl‐D‐aspartate receptor‐specific [(3)H]Ifenprodil binding to recombinant human NR1a/NR2B receptors compared with native receptors in rodent brain membranes. J. Neurochem. 75:2455‐2463
生物科学正迅速地演变为一门信息科学。最明显的一个例子就是目前正在进行的HGP（human genome project），最终要搞清人类全部基因组的30亿左右碱基对的序列。除了人的遗传信息以外，还有其它生物尤其是模式生物（model organism）已经或正在被大规模测序，如大肠杆菌、啤酒酵母、秀丽隐杆线虫以及中国和日本科学家攻关的水稻基因组计划。但单纯知晓生物基因组序列一级结构还远远不够，还必须了解其中基因是怎样组织起来的，每个基因的功能是什么，又是怎样随发育调控和微环境因素的影响而在特定
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