重组人KARS(赖氨酸-tRNA连接酶)(赖氨酰-tRNA合

特别提示：包括重组人KARS(赖氨酸-tRNA连接酶)(赖氨酰-tRNA合成酶)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人KARS(赖氨酸-tRNA连接酶)(赖氨酰-tRNA合成酶)
英文名称：Recombinant Human Lysine--tRNA Ligase
产品货号：JN0745
产品规格：10μg|50μg|500μg|1mg

本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Ala2-Val597在C端含有His标签。

KARS质量控制：＞95%(还原性SDS-PAGE)

KARS制剂：液体

KARS保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于KARS：
Lysine-tRNA ligase, also known as Lysyl-tRNA synthetase, LysRS, KARS and KIAA0070, belongs to the class-II aminoacyl-tRNA synthetase family. The N-terminal cytoplasmic domain (1-65) is a functional tRNA-binding domain, which is required for nuclear localization, is involved in the interaction with DARS, but has a repulsive role in the binding to EEF1A1. A central domain (208-259) is involved in homodimerization and is required for interaction with HIV-1 GAG and incorporation into virions. KARS catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Defects in KARS are the cause of Charcot-Marie-Tooth disease recessive intermediate type B (CMTRIB).

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