【产品介绍】表皮生长因子受体 (epidermal growth fact o r recept o r , EGFR)是一种广泛分布于人体各组织细胞膜上的多功能糖蛋白,具有酪氨酶激酶活性,为HER/ErbB 家族的四个成员之一,故又名HER1 或ErbB-1。EGFR及其配体是细胞信号传导系统的一部分,受体一旦与表皮生长因子(EGF)结合可启动细胞核内的有关基因,从而促进细胞分裂增殖。 研究表明,EGFR 基因拷贝数增加或者过度表达,均能促进正常细胞的转化和恶性肿瘤的转移。EGFR 的信号传导网络在肿瘤的形成和发展过程中占了重要的地位。从1984 年EGFR基因被首次克隆,20 年来的研究显示,EGFR 是治疗肿瘤的一个很有前景的靶分子。
Recombinant Human EGF Receptor (EGFR)
Product Details
Catalog Number:100-15R
Description:
EGF Receptor (EGFR, ErbB1) is a transmembrane protein that exerts tyrosine kinase activity upon ligand-induced activation. EGFR can be activated by binding EGF, or at least six other structurally related protein ligands, including TGF-α, HB-EGF, Betacellulin (BTC), Amphiregulin, Epiregulin, and Epigen. Upon activation, EGFR initiates a signaling cascade, which includes dimerization and internalization, tyrosine phosphorylation, DNA synthesis of target genes and, ultimately, cell proliferation. EGFR signaling plays a role in the growth and differentiation of normal cells, but elevated EGFR activity is correlated with the development and pathogenesis of certain cancers. Recombinant soluble Human EGFR is a 621 amino acid glycoprotein comprising the extracellular domain of EGFR, and migrates at an apparent MW of 97.5 kDa by SDS-PAGE analysis under reducing conditions.