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- peprotech
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- 2025年12月28日
- 兔
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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 抗体英文名：
BMP2
- 宿主：
兔
- 库存：
大量
- 抗原来源：
其它
- 供应商：
上海研卉生物科技有限公司
- 是否单克隆：
多克隆
- 规格：
10μg
Recombinant Human/Murine/Rat BMP-2 (E.coli derived)
Product Details
BMPs (Bone Morphogenetic Proteins) belong to the TGF-β superfamily of structurally related signaling proteins. BMP-2 is a potent osteoinductive cytokine, capable of inducing bone and cartilage formation in association with osteoconductive carriers such as collagen and synthetic hydroxyapatite. In addition to its osteogenic activity, BMP-2 plays an important role in cardiac morphogenesis, and is expressed in a variety of tissues, including lung, spleen, brain, liver, prostate ovary and small intestine. The functional form of BMP-2 is a 26 kDa protein composed of two identical 114 amino acid polypeptide chains linked by a single disulfide bond. Each BMP-2 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 23 amino acid signal sequence for secretion, and a 259 amino acid propeptide. After dimerization of this precursor, the covalent bonds between the propeptide (which is also a disulfide-linked homodimer) and the mature BMP-2 ligand are cleaved by a furin-type protease. Recombinant Human/Murine/Rat BMP-2 is a 26.0 kDa homodimeric protein consisting of two 115 amino acid polypeptide chains.
Source: E.coli
Synonyms: Bone Morphogenetic Protein-2, BMP-2A
AA Sequence (monomer): MQAKHKQRKR LKSSCKRHPL YVDFSDVGWN DWIVAPPGYH AFYCHGECPF PLADHLNSTN HAIVQTLVNS VNSKIPKACC VPTELSAISM LYLDENEKVV LKNYQDMVVE GCGCR
Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 0.5-1.0 μg/ml.
Product Details
Source: Polyclonal Rabbit
Preparation: Produced from sera of rabbits pre-immunized with highly pure (>98%) recombinant hBMP-2. Anti-Human BMP-2 specific antibody was purified by affinity chromatography employing immobilized hBMP-2 matrix.
Immunogen: E.coli derived Recombinant Human/Murine/Rat BMP-2 (PeproTech catalog# 120-02)
Sandwich ELISA: To detect hBMP-2 by sandwich ELISA (using 100 μl/well antibody solution) a concentration of 0.5 - 2.0 μg/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with PeproTech’s Biotinylated Anti-Human BMP-2 (500-P195Bt) as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant hBMP-2.
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光阴似箭，日月如梭。转眼已到 2 月中旬，科研人奋斗的步伐不能停。 本周学术君继续带来 CNS 最新进展，助力大家勇攀科研高峰！ 1. Nature：罕见遗传病中异常相分离和核仁功能障碍 无序蛋白质的突变可能会引起凝聚物的性质和功能的改变。 2023 年 2 月 8 日，德国马克斯普朗克分子遗传学研究所的 Denes Hnisz 团队在 Nature 杂志发表研究论文 Aberrant phase separation and nucleolar dysfunction
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