重组人分子伴侣辅因子(热休克蛋白70羧基末端相互作用蛋白)(

特别提示：包括重组人分子伴侣辅因子(热休克蛋白70羧基末端相互作用蛋白)(CHIP)(STUB1)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人分子伴侣辅因子(热休克蛋白70羧基末端相互作用蛋白)(CHIP)(STUB1)
英文名称：Recombinant Human E3 Ubiquitin-Protein Ligase CHIP
产品货号：JN1919
产品规格：10μg|50μg|500μg|1mg

本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Met1-Tyr303表达纯化得来。

STUB1/CHIP质量控制：＞95%(还原性SDS-PAGE)

STUB1/CHIP制剂：液体

STUB1/CHIP保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于STUB1/CHIP：
E3 Ubiquitin-Protein Ligase CHIP is a cytoplasmic protein. CHIP is highly expressed in skeletal muscle, heart, pancreas, brain and placenta. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its TPR domain; lead to in client substrate ubiquitylation and degradation by the proteasome. CHIP targets misfolded chaperone substrates towards proteasomal degradation. CHIP mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. CHIP plays a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. It also may regulate the receptor stability and activity through proteasomal degradation.

除了重组人分子伴侣辅因子(热休克蛋白70羧基末端相互作用蛋白)(CHIP)(STUB1),，我公司还供应以下相关产品：



名称：重组人TGFα(转化生长因子)
货号：JN0225
规格：10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备，目的基因编码的Val41-Val90表达纯化而来。

TGF-α质量控制：＞95%(还原性SDS-PAGE)。

TGF-α制剂：冻干品

TGF-α保存：
冻干蛋白可在-20℃长期保存，室温也可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天。
复溶后建议分装冻存在-20℃，可保存3个月，应避免反复冻融。

TGF-α复溶：
1、试剂开盖前请先离心。
2、复溶浓度应大于100 μg/ml.
3、冻干蛋白溶于ddH2O中
4、复溶后根据使用量分装保存，避免反复冻融。

关于TGF-α：
Transforming Growth Factor α (TGF-α) belongs to the EGF family of cytokines. It is a mitogenic polypeptide and secreted protein, which is expressed by monocytes, keratinocytes, and various tumor cells. TGFα contains two chains, protransforming growth factor α and transforming growth factor α. It can bind to the EGF receptor that synergistically with TGFβ to stimulate anchorage-independent cell proliferation and produce a mitogenic response. TGFα interacts with the PDZ domains of MAGI3, SDCBP and SNTA1. The interaction with SDCBP is required for the targeting to the cell surface.

名称：重组人MAN1B1
货号：JN0764
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Asp106-Ala699在C端含有His标签。

MAN1B1质量控制：＞95%(还原性SDS-PAGE)

MAN1B1制剂：液体

MAN1B1保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于MAN1B1：
Endoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-α-Mannosidase (MAN1B1) belongs to the glycosyl hydrolase 47 family. MAB1B1 is a single-pass type II membrane protein and widely expressed in many tissues. MAB1B1 is involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. MAB1B1 can be inhibited by both 1-deoxymannojirimycin (dMNJ) and kifunensine. Defects in MAN1B1 are the cause of mental retardation autosomal recessive type 15 (MRT15). Mental retardation is characterized by significantly below average general intellectual functioning, it is also associated with impairments in adaptative behavior and manifested during the developmental period.

名称：重组人SULT2B1(胞质磺基转移酶家族2B成员1)
货号：JN0924
规格：10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Met1-Glu311在C端含有His标签。

SULT2B1质量控制：＞95%(还原性SDS-PAGE)

SULT2B1制剂：液体

SULT2B1保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于SULT2B1：
Sulfotransferase Family Cytosolic 2B Member 1(SULT2B1) is a member of the Sulfotransferase 1 family. SULT2B1 is highly expressed in the placenta, prostate, and trachea with lower expression levels in the small intestine and lung. SULT2B1 catalyzes the sulfate conjugation of numerous hormones, neurotransmitters, drugs, and xenobiotic compounds. Sulfonation enhances the water solubility of molecules, and therefore their renal excretion, however SULT2B1 can also result in bioactivation to form active metabolites.

名称：重组人ABP1(阿米洛利结合蛋白1)
货号：JN1277
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Glu20-Val751在C端含有His标签。

ABP1质量控制：＞95%(还原性SDS-PAGE)

ABP1制剂：液体

ABP1保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于ABP1：
Amiloride-sensitive amine oxidase (AOC1) belongs to the copper/topaquinone oxidase family. The protein exists as homodimer by disulfide and mainly located in placenta and kidney. AOC1 catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function. The activity of this protein can be inhibited by amiloride in a competitive manner. It is inhibited by amiloride, a diuretic that acts by closing epithelial sodium ion channels.

名称：重组人FcγRIIA
货号：JN1817
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Ala36-Ile218在C端含有His标签。

FcγRIIA质量控制：＞95%(还原性SDS-PAGE)

FcγRIIA制剂：冻干品

FcγRIIA保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

FcγRIIA复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于FcγRIIA：
Receptors for the Fc region of IgG (FcγR) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Human FcγRs are divided into three classes designated FcγRI (CD64), FcγRII (CD32), and FcγRIII (CD16), which generate multiple isoforms, are recognized. The activating­ type receptor either has or associates non­covalently with an accessory subunit that has an immunoreceptor tyrosine­based activation motif (ITAM) in its cytoplasmic domain. FcγRI binds IgG with high affinity and functions during early immune responses, whereas FcγRII and RIII are low affinity receptors that recognize IgG as aggregates surrounding multivalent antigens during late immune responses. Three genes for human FcγRII (A, B, and C) and one for mouse (FcγRIIB), encoding type I transmembrane proteins with ITAM motifs (FcγRII A and C) or ITIM motifs (FcγRIIB) in their cytoplasmic domains, have been identified. Human CD32, also known as Low affinity immunoglobulin γ Fc region receptor II-a (IgG Fc receptor II-a), FcγRII A or FCGR2A Protein, is expressed on cells of both myeloid and lymphoid lineages as well as on cells of non-hematopoietic origin. Associated with an ITAM-bearing adapter subunit, FcRγ, CD32a (FcγRII A) delivers an activating signal upon ligand binding, and results in the initiation of inflammatory responses including cytolysis, phagocytosis, degranulation, and cytokine production. The responses can be modulated by signals from the co-expressed inhibitory receptors such as Fcγ RII B, and the strength of the signal is dependent on the ratio of expression of the activating and inhibitory receptors.