重组人PTPRN(受体型蛋白酪氨酸磷酸酶N)

特别提示：包括重组人PTPRN(受体型蛋白酪氨酸磷酸酶N)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人PTPRN(受体型蛋白酪氨酸磷酸酶N)
英文名称：Recombinant Human Islet Cell Antigen 2/Protein Tyrosine Phosphatase Receptor-type N
产品货号：JN1778
产品规格：10μg|50μg|500μg|1mg

本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Met687-Gln979在N端含有His标签。

PTPRN质量控制：＞95%(还原性SDS-PAGE)

PTPRN制剂：液体

PTPRN保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于PTPRN：
Receptor-type tyrosine-protein phosphatase-like N (PTPRN) belongs to the protein-tyrosine phosphatase family and receptor class 8 subfamily. PTPRN contains 1 tyrosine-protein phosphatase domain, is expressed in neuroendocrine cells only. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. It implicated in neuroendocrine secretory processes. It may be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. It seems to lack intrinsic enzyme activity, may play a role in the regulation of secretory granules via its interaction with SNTB2.This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus.

除了重组人PTPRN(受体型蛋白酪氨酸磷酸酶N),，我公司还供应以下相关产品：



名称：重组人FGFRL1(成纤维细胞生长因子受体样因子1)(带His标签)
货号：JN0236
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物表达系统制备，目的基因编码的Ala25-Pro378在C端含有His标签。

FGFRL1质量控制：＞95%(还原性SDS-PAGE)。

FGFRL1制剂：冻干品

FGFRL1保存：
冻干蛋白可在-20℃长期保存，室温也可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天。
复溶后建议分装冻存在-20℃，可保存3个月，应避免反复冻融。

FGFRL1复溶：
1、试剂开盖前请先离心。
2、复溶浓度应大于100 μg/ml.
3、冻干蛋白溶于ddH2O中
4、复溶后根据使用量分装保存，避免反复冻融。

关于FGFRL1：
Fibroblast Growth Factor Receptor-Like 1 (FGFRL1) is a single-pass type I membrane protein that belongs to the FGF receptor family. The mature human FGFRL1 consists of a 354 amino acid extracellular domain (ECD) with 3 Ig-like C2-type domains, a 21 amino acid transmembrane segment, and a 134 amino acid cytoplasmic domain. FGFR1 expressed in various tissues, preferentially in cartilaginous tissues and pancreas. It highly expressed in the liver, kidney, heart, brain and skeletal muscle, weakly expressed in the lung, small intestine and spleen. FGFRL1 has a negative effect on cell proliferation.