N-Oxalylglycine α-酮戊二酸依赖性酶(包括JMJD2A,JMJD2C和JMJD2E)的细胞渗透性抑制剂 CAS:5262-39-5 货号C3095
N-Oxalylglycine α-酮戊二酸依赖性酶(包括JMJD2A,JMJD2C和JMJD2E)的细胞渗透性抑制剂化学性质
CAS号 |
5262-39-5 |
SDF |
Download SDF |
别名 |
NOG |
化学名 |
N-(carboxycarbonyl)-glycine |
SMILES |
OC(C(NCC(O)=O)=O)=O |
分子式 |
C4H5NO5 |
分子量 |
147.1 |
溶解性 |
Soluble in DMSO |
储存条件 |
Store at -20°C |
运输条件 |
试用装:蓝冰运输。 其他可选规格:常温运输或根据您的要求用蓝冰运输。 |
一般建议 |
为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。 |
N-Oxalylglycine α-酮戊二酸依赖性酶(包括JMJD2A,JMJD2C和JMJD2E)的细胞渗透性抑制剂产品描述
IC50: 250 μM: inhibits α-ketoglutarate-dependent enzyme jumonji domain-containing protein 2 (JMJD2) A.
IC50: 500 μM: blocks α-ketoglutarate-dependent enzyme JMJD2C.
IC50: 24 μM: dampens α-ketoglutarate-dependent enzyme JMJD2E.
IC50: 2.1 μM: suppresses the prolyl hydroxylase domain-containing proteins PHD1.
IC50: 5.6 μM: depresses the prolyl hydroxylase domain-containing proteins PHD2.
N-Oxalylglycine, as known as NOG, is a cell permeable inhibitor of α-ketoglutarate-dependent enzymes which include JMJD2A, JMJD2C, and JMJD2E. NOG also blocks the prolyl hydroxylase domain-containing proteins PHD1 and PHD2. Demethylation of the methylated forms of histone 3 lysine 9 (H3K9) and H3K36 can be catalyzed by JMJD2 subfamily of histone demethylases. Since histone demethylases are related to certain diseases, including cancer, selective inhibitors functions as anticancer agents and potential tools for clarifying the biological functions of JMJDs.
In vitro: NOG was identified as a natural product and presented in plants, including Rheum rhabarbarum (rhubarb) and Spinach oleracea (spinach) leaves. However, there was no NOG observed human embryonic kidney cells (HEK 293T) or Escherchia coli. NOG regulated gene expression via blocking 2-Oxoglutarate-dependent oxygenases [1].
In vivo: Up to now, in vivo study of NOG is still in the development stage.
Reference:
[1]. Al-Qahtani, K., Jabeen, B., Sekirnik, R., Riaz, N., Claridge, T., Schofield, C., & McCullagh, J. The broad spectrum 2-oxoglutarate oxygenase inhibitor N-oxalylglycine is present in rhubarb and spinach leaves. Phytochemistry. 2015; 117: 456-461.
N-Oxalylglycine α-酮戊二酸依赖性酶(包括JMJD2A,JMJD2C和JMJD2E)的细胞渗透性抑制剂上海恒斐生物现货供应说明书及抑制剂详情请联系上海恒斐生物021-60493872 刘鑫 17317793691(微信同步)QQ845206284