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文献和实验Antisense Efficacy: Site-Restricted In Vivo and Ex Vivo Models
In the laboratory, antisense oligodeoxynucleotides (ODN) have repeatedly demonstrated efficacy in modulating the expression of various genes, thus providing important insights into their roles in tumorigenesis or normal growth and development
Modulation of human interferon- biosynthesis by antisense oligodeoxynucleotides
We investigated the inhibition of human interferon-γ (HuIFN-γ) production in cultures of lymphocytes with the use of the antisense strategy. Out of a series of antisense oligodeoxynucleotides (ODN) complementary to different regions of the HuIFN
Transport of Antisense Across the Blood-Brain Barrier
. Recently, two types of unmodified antisense analogs have been shown to effectively cross the BBB and affect CNS function. One of the analogs, a phosphorothioate oligodeoxy-nucleotide (P-ODN) directed against the amyloid β protein, was peripherally
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