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- 详细信息
- 技术资料
- 抗体名:
核受体0相关蛋白B家族2抗体价格
- 抗体英文名:
Anti-NR0B2/SHP
- 靶点:
详见说明书
- 浓度:
1mg/1ml
- 应用范围:
WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
- 宿主:
详见说明书
- 供应商:
上海博湖
- 库存:
大量
- 级别:
详见说明书
- 目录编号:
详见说明书
- 抗原来源:
Rabbit
- 保质期:
详见说明书
- 适应物种:
详见说明书
- 标记物:
详见说明书
- 克隆性:
多克隆
- 保存条件:
Store at -20 °C
- 形态:
详见说明书
- 亚型:
IgG
- 免疫原:
KLH conjugated synthetic peptide derived from human NR0B2
- 规格:
0.2ml/200μg
中文名称 核受体0相关蛋白B家族2抗体价格
英文名称 Anti-NR0B2/SHP
别 名 NR0B2; NR0B2_HUMAN; Nr0b2a; Nuclear receptor subfamily 0 group B member 2; Nuclear receptor subfamily 0, group B, member 2a; Orphan nuclear receptor SHP; SHP; SHP-1; Shp1; Small heterodimer partner.
核受体0相关蛋白B家族2抗体价格是用于化学反应、分析化验、研究实验、教学实验、化学配方使用的纯净化学品,产品品质卓越,价格实惠,多种规格供应,售后完善。
浓 度 1mg/1ml
规 格 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Rabbit
产品类型 一抗
研究领域 肿瘤 染色质和核信号 信号转导 转录调节因子 表观遗传学
蛋白分子量 predicted molecular weight: 28kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human NR0B2
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
核受体0相关蛋白B家族2抗体价格产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 SHP is an orphan nuclear receptor containing the dimerization and ligand-binding domains found in other nuclear receptors, but lacking the conserved DNA binding domain. SHP is specifically expressed in liver and other tissues, including fetal liver and adrenal gland, as well as adult spleen and small intestine. In addition, SHP is highy expressed in the murine macrophage cell line RAW 264.7 but suppressed by oxLDL and 13-HODE, which is a ligand for PPARg. SHP interacts with nuclear receptors, including thyroid receptor, retinoic acid receptors (RAR and RXR) and estrogen receptors (ERa and ERb). SHP functions as a negative regulator of these receptors by at least three mechanisms: inhibition of DNA binding via dimerization, direct antagonism of coactivator function through competition and possibly transrepression via recruitment of putative corepressors. In oxLDL-treated, resting macrophage cells, SHP acts as a transcription coactivator of NFkB, suggesting that SHP is a modulatory component in the regulation of the transcriptional activities of NFkB. Lastly, negative feedback regulation of a hepatic bile acid transporter, NTCP, is controlled by bile acid-activated FXR via induction of SHP to protect the hepatocyte from bile acid-mediated damage in cholestatic conditions.
Function : Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts.Subunit : Interacts with RARA, RXRA, THRB, NR5A1, NR5A2, NR1I3, PPARA, PPARG and EID1. May also interact with HNF4A (By similarity). Heterodimer; efficient DNA binding requires dimerization with another bHLH protein. Interacts (via N-terminus) with NEUROD1 (via N-terminus an C-terminus). Interacts with ID2.Subcellular Location : Nucleus. Cytoplasm. Note=Colocalizes with NEUROD1 in the nucleus.Tissue Specificity : Liver. Low levels of expression were detected in heart and pancreas.DISEASE : Defects in NR0B2 may be associated with obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.Similarity : Belongs to the nuclear hormone receptor family. NR0 subfamily.
核受体0相关蛋白B家族2抗体价格具有全、新、优、品、好四大特点:
全:公司提供上万种产品,涵盖了生物试剂,elisa试剂盒,标准品,培养基,原装耗材,抗体、培养基、ATCC细胞等,基本上各种科研所需产品在我司都能找到。
新:产品更新速度较快,基本上每周都有新产品出现。
优:产品质量好,投诉比较少。
好:我公司具有优质的技术团队,产品一旦售出,实验过程中遇到困难可提供在线技术咨询。使您使用产品时没有任何的后顾之忧。
我们提供的标记服务,可根据您科研的需求,满足您的需要,质量保证,价格合理。
一、标记流程
委托标记服务,请下载并详细填写《委托标记申请单》,待我公司标记室技术人员研究、确认后答复,并办理委托标记事宜。
二、各种标记物制备的收费标准(RMB)
我们不但提供抗体和大分子蛋白的标记服务,还提供小分子多肽及小分子蛋白的各种标记服务,提供标记化合物的服务(此化合物必须适用于标记),价格另议。
一抗和二坑的区别:
第一抗体就是平常所说的抗体,即能和抗原特异性结合。
第二抗体是能和抗体结合的,即抗体的抗体。主要用于检测抗体的存在。
一抗是针对抗原的抗体,二抗是针对一抗的抗体。即抗体也可以充当抗原刺激机体产生抗体。也就是说,抗原进入机体刺激机体免疫系统产生免疫应答,由B细胞可以产生与相应抗原发生特异性结合的特殊蛋白质。
一抗二抗都是一种可以特异结合别的物质的基团,而且一抗可以至少结合两种其他基团(底物和二抗)。
一抗:可以特异结合底物,就是识别出我们想要检测的东西。一抗和底物结合与否用肉眼是看不出来的。
二抗:可以和一抗结合,并带有可以被检测出的标记(如带荧光、放射性、化学发光或显色基团),作用是检测一抗。 如果一抗自己带有可以被检测出的标记(如带荧光、放射性、化学发光或显色基团),则不需要二抗。但这样成本很高,因为一种一抗只识别一种底物。所以如今的设计一般是二抗带上可检测标记,再来检测一抗。而一抗识别底物。这样,当一抗结合到底物上,就可以通过二抗检测出来。
Immunoprecipitation/ IP Kit - Anti-CD30 / TNFRSF8 Immunomagnetic Beads IP 5 mL
Immunoprecipitation/ IP Kit - Anti-CD48 / SLAMF2 Immunomagnetic Beads IP 5 mL
Immunoprecipitation/ IP Kit - Anti-JNK2 / MAPK9 Immunomagnetic Beads IP 5 mL
Immunoprecip
Vitronectin / VTN 抗體, 兔單抗 ELISA 50 µg
BMP-2 抗體, 鼠單抗 WB 50 µg
Vitronectin / VTN 抗體, 鼠單抗 ELISA 50 µg
Vitronectin 抗體, 兔多抗 ELISA WB 200 µg
BMP-2 抗體, 鼠單抗 IF ICC/IF 50 µg
CD200RLa / CD200R1L 抗體, 兔多抗, 抗原親和純化 ELISA 50 µg
CD200RLa / CD200R1L 抗體, 兔多抗 ELISA 400 µg
LTC4S 抗體, 兔多抗 ELISA 400 µg
NME1 / NDKA 抗體, 兔多抗, 抗原親和純化 ELISA WB IP 50 µg
RAGE / AGER 抗體, 兔多抗, 抗原親和純化 ELISA 50 µg
用于酸性罐头食品商业无菌检验 麦芽浸膏汤 250g
用于酵母和霉菌的培养,还用于酸性罐头食品商业无菌检验(GB/T4789.26-2003)。 麦芽浸膏汤 250g
细菌生化鉴定 麦芽糖生化鉴定管 20支/盒
培养基原材料,特制适用于培养酵母菌 麦芽提取粉 400g
用于酵母菌的增菌培养 麦芽汁培养基 250g
NAC琼脂培养基 250g
NAC液体培养基 250g
NGKG寒天基础培地 250g
0.1%溶菌酶溶液 1ml*5
邻单胞菌鉴别琼脂 250g
核受体0相关蛋白B家族2抗体价格人叶酸受体1(FOLR1)ELISA试剂盒 0.156-10 ng/mL
ELISA Kit for Human Folate receptor alpha 0.156-10 ng/mL
人高亲和力γ免疫球蛋白FC段受体I(IgG Fc receptor I)ELISA试剂盒 78-5000 pg/mL
ELISA Kit for Human High affinity immunoglobulin gamma Fc receptor I 78-5000 pg/mL
人低亲和力免疫球蛋白Fc区Ⅲ受体γ(FCG3A)ELISA试剂盒 15.6-1000 pg/ml
英文名称 Anti-NR0B2/SHP
别 名 NR0B2; NR0B2_HUMAN; Nr0b2a; Nuclear receptor subfamily 0 group B member 2; Nuclear receptor subfamily 0, group B, member 2a; Orphan nuclear receptor SHP; SHP; SHP-1; Shp1; Small heterodimer partner.
核受体0相关蛋白B家族2抗体价格是用于化学反应、分析化验、研究实验、教学实验、化学配方使用的纯净化学品,产品品质卓越,价格实惠,多种规格供应,售后完善。
浓 度 1mg/1ml
规 格 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Rabbit
产品类型 一抗
研究领域 肿瘤 染色质和核信号 信号转导 转录调节因子 表观遗传学
蛋白分子量 predicted molecular weight: 28kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human NR0B2
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
核受体0相关蛋白B家族2抗体价格产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 SHP is an orphan nuclear receptor containing the dimerization and ligand-binding domains found in other nuclear receptors, but lacking the conserved DNA binding domain. SHP is specifically expressed in liver and other tissues, including fetal liver and adrenal gland, as well as adult spleen and small intestine. In addition, SHP is highy expressed in the murine macrophage cell line RAW 264.7 but suppressed by oxLDL and 13-HODE, which is a ligand for PPARg. SHP interacts with nuclear receptors, including thyroid receptor, retinoic acid receptors (RAR and RXR) and estrogen receptors (ERa and ERb). SHP functions as a negative regulator of these receptors by at least three mechanisms: inhibition of DNA binding via dimerization, direct antagonism of coactivator function through competition and possibly transrepression via recruitment of putative corepressors. In oxLDL-treated, resting macrophage cells, SHP acts as a transcription coactivator of NFkB, suggesting that SHP is a modulatory component in the regulation of the transcriptional activities of NFkB. Lastly, negative feedback regulation of a hepatic bile acid transporter, NTCP, is controlled by bile acid-activated FXR via induction of SHP to protect the hepatocyte from bile acid-mediated damage in cholestatic conditions.
Function : Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts.Subunit : Interacts with RARA, RXRA, THRB, NR5A1, NR5A2, NR1I3, PPARA, PPARG and EID1. May also interact with HNF4A (By similarity). Heterodimer; efficient DNA binding requires dimerization with another bHLH protein. Interacts (via N-terminus) with NEUROD1 (via N-terminus an C-terminus). Interacts with ID2.Subcellular Location : Nucleus. Cytoplasm. Note=Colocalizes with NEUROD1 in the nucleus.Tissue Specificity : Liver. Low levels of expression were detected in heart and pancreas.DISEASE : Defects in NR0B2 may be associated with obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.Similarity : Belongs to the nuclear hormone receptor family. NR0 subfamily.
核受体0相关蛋白B家族2抗体价格具有全、新、优、品、好四大特点:
全:公司提供上万种产品,涵盖了生物试剂,elisa试剂盒,标准品,培养基,原装耗材,抗体、培养基、ATCC细胞等,基本上各种科研所需产品在我司都能找到。
新:产品更新速度较快,基本上每周都有新产品出现。
优:产品质量好,投诉比较少。
好:我公司具有优质的技术团队,产品一旦售出,实验过程中遇到困难可提供在线技术咨询。使您使用产品时没有任何的后顾之忧。
我们提供的标记服务,可根据您科研的需求,满足您的需要,质量保证,价格合理。
一、标记流程
委托标记服务,请下载并详细填写《委托标记申请单》,待我公司标记室技术人员研究、确认后答复,并办理委托标记事宜。
二、各种标记物制备的收费标准(RMB)
我们不但提供抗体和大分子蛋白的标记服务,还提供小分子多肽及小分子蛋白的各种标记服务,提供标记化合物的服务(此化合物必须适用于标记),价格另议。
一抗和二坑的区别:
第一抗体就是平常所说的抗体,即能和抗原特异性结合。
第二抗体是能和抗体结合的,即抗体的抗体。主要用于检测抗体的存在。
一抗是针对抗原的抗体,二抗是针对一抗的抗体。即抗体也可以充当抗原刺激机体产生抗体。也就是说,抗原进入机体刺激机体免疫系统产生免疫应答,由B细胞可以产生与相应抗原发生特异性结合的特殊蛋白质。
一抗二抗都是一种可以特异结合别的物质的基团,而且一抗可以至少结合两种其他基团(底物和二抗)。
一抗:可以特异结合底物,就是识别出我们想要检测的东西。一抗和底物结合与否用肉眼是看不出来的。
二抗:可以和一抗结合,并带有可以被检测出的标记(如带荧光、放射性、化学发光或显色基团),作用是检测一抗。 如果一抗自己带有可以被检测出的标记(如带荧光、放射性、化学发光或显色基团),则不需要二抗。但这样成本很高,因为一种一抗只识别一种底物。所以如今的设计一般是二抗带上可检测标记,再来检测一抗。而一抗识别底物。这样,当一抗结合到底物上,就可以通过二抗检测出来。
Immunoprecipitation/ IP Kit - Anti-CD30 / TNFRSF8 Immunomagnetic Beads IP 5 mL
Immunoprecipitation/ IP Kit - Anti-CD48 / SLAMF2 Immunomagnetic Beads IP 5 mL
Immunoprecipitation/ IP Kit - Anti-JNK2 / MAPK9 Immunomagnetic Beads IP 5 mL
Immunoprecip
Vitronectin / VTN 抗體, 兔單抗 ELISA 50 µg
BMP-2 抗體, 鼠單抗 WB 50 µg
Vitronectin / VTN 抗體, 鼠單抗 ELISA 50 µg
Vitronectin 抗體, 兔多抗 ELISA WB 200 µg
BMP-2 抗體, 鼠單抗 IF ICC/IF 50 µg
CD200RLa / CD200R1L 抗體, 兔多抗, 抗原親和純化 ELISA 50 µg
CD200RLa / CD200R1L 抗體, 兔多抗 ELISA 400 µg
LTC4S 抗體, 兔多抗 ELISA 400 µg
NME1 / NDKA 抗體, 兔多抗, 抗原親和純化 ELISA WB IP 50 µg
RAGE / AGER 抗體, 兔多抗, 抗原親和純化 ELISA 50 µg
用于酸性罐头食品商业无菌检验 麦芽浸膏汤 250g
用于酵母和霉菌的培养,还用于酸性罐头食品商业无菌检验(GB/T4789.26-2003)。 麦芽浸膏汤 250g
细菌生化鉴定 麦芽糖生化鉴定管 20支/盒
培养基原材料,特制适用于培养酵母菌 麦芽提取粉 400g
用于酵母菌的增菌培养 麦芽汁培养基 250g
NAC琼脂培养基 250g
NAC液体培养基 250g
NGKG寒天基础培地 250g
0.1%溶菌酶溶液 1ml*5
邻单胞菌鉴别琼脂 250g
核受体0相关蛋白B家族2抗体价格人叶酸受体1(FOLR1)ELISA试剂盒 0.156-10 ng/mL
ELISA Kit for Human Folate receptor alpha 0.156-10 ng/mL
人高亲和力γ免疫球蛋白FC段受体I(IgG Fc receptor I)ELISA试剂盒 78-5000 pg/mL
ELISA Kit for Human High affinity immunoglobulin gamma Fc receptor I 78-5000 pg/mL
人低亲和力免疫球蛋白Fc区Ⅲ受体γ(FCG3A)ELISA试剂盒 15.6-1000 pg/ml
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核受体0相关蛋白B家族2抗体价格
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