Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
适应物种:
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
免疫原:
详见说明书
亚型:
IGg
形态:
粉末、液体、冻干粉
应用范围:
Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200
浓度:
1mg/ml
保存条件:
-20 °C
规格:
100ul
FITC标记的促血管平滑肌细胞分化因子抗体
英文名称
Anti-Myocardin/FITC
中文名称
FITC标记的促血管平滑肌细胞分化因子抗体
别 名
MYCD; MYCD_HUMAN; Myocardin; Myocd.
规格价格
100ul/2980元 购买 大包装/询价
说 明 书
100ul
研究领域
心血管 免疫学 转录调节因子 表观遗传学
抗体来源
Rabbit
克隆类型
Polyclonal
交叉反应
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
产品应用
Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分 子 量
103kDa
性 状
Lyophilized or Liquid
浓 度
1mg/ml
免 疫 原
KLH conjugated synthetic peptide derived from human Myocardin
亚 型
IgG
纯化方法
affinity purified by Protein A
储 存 液
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍
background: Transcriptional factor that uses the canonical single or multiple CArG boxes DNA sequence. Binds CArG boxes only in the presence of serum response factor (SRF). Acts as a cofactor of SRF and modulates SRF-target genes. Regulates the expression of a set of cardiac and smooth muscle-specific genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage.
Function: Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis).
Subunit: Homodimer. Interacts with SRF, its association does not depend on specific DNA sequences for ternary complex formation. Interacts with MLLT7/FOXO4. Interacts (via C-terminal) with EP300 (via the CREB-binding domain). Interacts with HDAC4 and HDAC5 (By similarity). Interacts with MEF2C.
Subcellular Location: Nucleus.
Tissue Specificity: Expressed in heart, aorta, and in smooth muscle cell-containing tissues: stomach, bladder, small intestine, colon, lung, placenta and uterus. Very faint expression in prostate and skeletal muscle.
Post-translational modifications: Phosphorylation regulates negatively the intrinsic myocardin transcriptional activity.
Similarity: Contains 3 RPEL repeats. Contains 1 SAP domain.
Database links:
Entrez Gene: 93649 Human
Entrez Gene: 214384 Mouse
Entrez Gene: 396571 Pig
Entrez Gene: 246297 Rat
Omim: 606127 Human
SwissProt: Q8IZQ8 Human
SwissProt: Q8VIM5 Mouse
SwissProt: Q8R5I7 Rat
Unigene: 567641 Human
Unigene: 32257 Mouse
Unigene: 163103 Rat
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.