SPPL2B; IMP4; Signal peptide peptidase-like 2B; Intramembrane protease 4; Protein SPP-like 2B; SPPL2B; SPP2B_HUMAN.
规格价格
100ul/2980元 购买 大包装/询价
说 明 书
100ul
研究领域
细胞生物 神经生物学 信号转导 细胞粘附分子 泛素 Alzheimer's
抗体来源
Rabbit
克隆类型
Polyclonal
交叉反应
Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
产品应用
ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分 子 量
65kDa
细胞定位
细胞膜
性 状
Lyophilized or Liquid
浓 度
1mg/ml
免 疫 原
KLH conjugated synthetic peptide derived from human SPPL2B (55-135aa)
亚 型
IgG
纯化方法
affinity purified by Protein A
储 存 液
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件
Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
产品介绍
background: This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function: The SPPLs are a group of aspartic proteases that are responsible for proteolysis of type II membrane-anchored signalling factors. SPPL2b, unlike other SPPL family members is found in endosomes/lysosomes, and not the endoplasmic reticulum, and has a role in catalysing intramembrane cleavage of tumour necrosis factor alpha (TNFalpha).
Subunit: Monomer. Homodimer. Interacts with ITM2B and TNF.
Subcellular Location: Membrane; multi-pass membrane protein of endosomes/lysosomes.
Tissue Specificity: Expressed predominantly in adrenal cortex and mammary gland.
Post-translational modifications: Glycosylated.
Similarity: Belongs to the peptidase A22B family. Contains 1 PA (protease associated) domain.
Database links:
Entrez Gene: 56928 Human
SwissProt: Q8TCT7 Human
Unigene: 330742 Human
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.