- $265
- Ybscience
- Yb--1709
- 美国/德国/中国
- 2025年07月13日
- WB IHC IF/ICC
- Human
- 详见说明书
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- 详细信息
- 文献和实验
- 技术资料
- 抗体名：
CLDN6 Antibody
- 抗体英文名：
CLDN6 Antibody
- 靶点：
详见说明书
- 浓度：
1.0mg/ml
- 应用范围：
WB IHC IF/ICC
- 宿主：
Human
- 供应商：
上海钰博生物科技有限公司
- 库存：
大量
- 目录编号：
1709
- 抗原来源：
Human
- 保质期：
1年
- 适应物种：
详见说明书
- 标记物：
详见说明书
- 克隆性：
多克隆
- 保存条件：
Store at -20°C
- 形态：
液体或冻干粉
- 亚型：
详见说明书
- 免疫原：
详见说明书
- 规格：
50μg/50μl, 100μg/100μl
-
- Catalog No. : Yb--1709
- Size : 50μg/50μl, 100μg/100μl
-
- Mol Weight : 26 KD
- UniProt : P56747
-
- Isotype : Rabbit IgG
- Clonality : Polyclonal
-
- Price : $265/100μg
- Availability : Ship next day
Category
- Primary Antibodies
- Secondary antibody
- Loading control / tag antibody
Details
Alternative Names:
claudin 6; claudin-6; CLD6; Skullin 2
Application:
WB IHC IF/ICC
Reactivity:
Human
Dilution:
WB 1:500~1:1000 IHC: 1:50~1:200 IF/ICC 1:100-1:500
 |
Western blot analysis of extracts from Jurkat cells, using CLDN6 antibody. |
Purification:
Affinity-chromatography
Specificity:
CLDN6 Antibody detects endogenous levels of total CLDN6
Immunogen:
A synthesized peptide derived from human CLDN6
Description:
Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity). May act as a coreceptor for HCV entry ihepatic cells.
Storage Condition and Buffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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文献和实验STM：广州医科大学刘铭/谢茂彬合作发现肝细胞癌的新潜在治疗靶点 Claudin 6
组于 Science Translational Medicine 杂志（STM）在线发表题为 Targeting tumor lineage plasticity in hepatocellular carcinoma using an anti-CLDN6 antibody-drug conjugate 的研究论文。这项研究揭示了细胞紧密连接（tight junction）蛋白 Claudin 6 通过调控肝癌细胞的谱系可塑性（lineage plasticity），促进肝癌进展与耐药的机制，并初步报道
Generation of Antibody Molecules Through Antibody Engineering
been overcome to a large extent using genetic-engineering techniques to produce chimeric mouse/human and completely human antibodies. Such an approach is particularly suitable because of the domain structure of the antibody molecule ( 2 ), where functional
The importance of antibody molecules was first recognized in the 1890s, when it was shown that immunity to tetanus and diphtheria was caused by antibodies against the bacterial exotoxins (1 ). Around the same time, it was shown that antisera
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