CBZ-缬更昔洛韦 CBZ-valganciclovir 1

Synthesis of Cbz-Protected Ketomethylene Dipeptide Isosteres

1 are chemically characterized by a 1,4-disposition of the carbonyl groups (ketone and carboxylate) and have an alkyl group at C-2 that is a chiral center. Protecting groups at amino nitrogen (typically carbamate such as Cbz or Boc) and the carboxyl group

Preparation of Carboxypeptidase Y and Its Properties

through polyacrylamide gel electrophoresis. Carboxypeptidase Y possesses the activity of esterase and peptase that can be assayed using N-acetyl-L-tyrosine ethyl ester (ATEE) and benzyloxycarbonyl-L-phenylalanyl-L-leucine (CBZ-Phe-Leu) as substrates respectively

A Method for Assaying Deubiquitinating Enzymes

using 125 I-labeled Ub-PESTc. We also compare the sensitivity of this method to that using a fluorogenic peptide substrate, carbobenzoxy-LRGG-7-amido-4-methylcoumarin (Cbz-LRGG-AMC), that has also been used as a substrate for DUBs (19 ). 20