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- 库存：
大量
- 供应商：
上海研卉生物科技有限公司
- 英文名：
Recombinant Rat Interleukin-17E
- 规格：
25μg
Recombinant Human IL-17E
Product Details
IL-17E is a disulfide-linked homodimer of two 145 amino acid polypeptide chains. It belongs to the IL-17 family of structurally-related cytokines that share a highly conserved C-terminal region, but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17E stimulates secretion of IL-8, and induces activation of the transcription factor NF-κB in cells that express the IL-17BR receptor. Recombinant Human IL-17E is a 33.8 kDa disulfide-linked homodimer of two 146 amino acid polypeptide chains.
Source: E.coli
Synonyms: Interleukin-17E, IL-25
AA Sequence (monomer): MYSHWPSCCP SKGQDTSEEL LRWSTVPVPP LEPARPNRHP ESCRASEDGP LNSRAISPWR YELDRDLNRL PQDLYHARCL CPHCVSLQTG SHMDPRGNSE LLYHNQTVFY RRPCHGEKGT HKGYCLERRL YRVSLACVCV RPRVMG
Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity: Determined by its ability to induce IL-8 in human PBMCs using a concentration range of 10-100 ng/ml.
Note:
1mg will be provided as 2x500μg.
| First Author | Title | Citation | Date | Pubmed |
|---|---|---|---|---|
| Silacci, M | Linker length matters, fynomer-Fc fusion with an optimized linker displaying picomolar IL-17A inhibition potency. | The Journal of Biological Chemistry; 289(20) pg14392-8 | 16 May 2014 | 24692552 Show Usages |
| Han, K | A Pilot Study To Investigate the Immune-Modulatory Effects of Fasting in Steroid-Naive Mild Asthmatics. | Journal of immunology (Baltimore, Md. : 1950); 201(5) pg1382-1388 | 1 Sep 2018 | 30021766 Show Usages |
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