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Zedira特约代理

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  • 2025年07月03日
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    上海沪震实业有限公司
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    • 英文名：

      Zedira

    • 供应商：

      上海沪震实业有限公司

    Zedira特约代理
     

    货号： Zedira
    Zedira特约代理
    Zedira货号：
    Zedira
    Zedira品牌名称：
    Zedira
    Zedira品牌Logo：
    产品细节图片1
    Zedira官网：
    https://zedira.com/
    Zedira品牌介绍：

    Zedira is a clinical stage biotech company specialised in transglutaminase.

    Zedira conducts its own development of small molecular drug candidates. In doing so, the company is working at the cutting edge of drug discovery involving small molecules that block dysregulated transglutaminases.

    In addition, Zedira is a global brand for specialty reagents for research & development as well as diagnostics in the transglutaminase field. Numerous unique and high quality products help pushing forward transglutaminase-related science – both in academia and industry.

    Martin Hils and Ralf Pasternack, 
    managing partners of Zedira founded the company in 2007. 

    “Transglutaminase is our inspiration – improving health and creating value is our mission.“

    Drug Development (clinical phase I)
    TG2-blocker
    Zedira’s lead indication is celiac disease – a widespread disorder suffered by about 1% of the population and for which there is no therapeutic option available apart from a cumbersome and quality of life restricting gluten-free diet.
    Inhibiting tissue transglutaminase (TG2) in the small intestinal mucosa with our drug candidate ZED1227 (first-in class) shall interrupt the mechanism of gluten intolerance in a targeted way. The compound is licensed to Dr. Falk Pharma for Europe. Dr. Falk Pharma took over responsibility for preclinical and clinical development as well as for approval and marketing of the drug.

    Zedira now taps the potential of ZED1227 to address additional indications where dysregulated tissue transglutaminase (TG2) activity is targeted, especially fibrotic disorders (e.g. diabetic nephropathy).

    Drug Discovery (lead optimization / drug candidates)
    FXIIIa-blocker
    Using a rabbit animal model, Zedira showed the proof-of-principle of “safe” anticoagulation therapy by inhibition of blood plasma transglutaminase (Factor XIII, F13), which allows selective intervention in the coagulation cascade.
    The crucial difference compared with the existing anticoagulants lies in the fact that a soft, easily degradable blood clot can still be formed while thrombin generation – and therefore thrombocyte function – is not affected.
    A significant reduction in the life-threatening tendency to bleeding as provoked by current drugs is thus likely to be achieved. Today about 50% of patients are excluded from anticoagulation therapy due to the risk of bleeding events.
    Therefore, an anticoagulant drug with a superior safety profile can look forward to a most attractive billion dollar market.

    Specialist for Transglutaminase
    Zedira has offered more than 200 specialty reagents for transglutaminase-related R&D for about 15 years.
    Today, Zedira is the global brand for transglutaminase. Researchers from academia and industry (including 12 of the top 15 big pharma companies) benefit from Zedira’s cutting edge products – and in an increasing manner – from customised services. 
    Solutions for site specific labeling of proteins using transglutaminases form Zedira’s latest product field.

    Zedira是一家专业做临床研究的生物技术公司，专门从事转谷氨酰胺酶领域。具有200多种转谷氨酰胺酶相关研发专用试剂。来自学术界和行业（包括前15大大型制药公司中的12家）的研究人员得益于Zedira的尖端产品定制服务。

    Zedira相关产品
    No. 品牌 货号 名称 规格
    1 Zedira T009 Human keratinocyte transglutaminase 150ug
    2 Zedira T035 Human keratinocyte transglutaminase,insect cells 150ug
    3 Zedira T002 Human tissue transglutaminase 250ug
    4 Zedira T018 Inactive human tissue transglutaminase 250ug
    5 Zedira T022 Human tissue transglutaminase,insect cells 250ug
    6 Zedira T034 Human tissue transglutaminase,human embryonic kidney cells 100ug
    7 Zedira T067 Human tissue transglutaminase, endotoxin free 250ug
    8 Zedira T117 Biotinylated inactive hTG2 (Cys277Ser) 250ug
    9 Zedira A115 (ATTO-700TM)cadaverine 1mg
    10 Zedira B002 N-(Biotinyl)cadaverine 25mg
    11 Zedira D007 Cadaverine (1,5-Diaminopentane) 100mg
    12 Zedira D009 "DALP-methyl carbamate" 5mg
    13 Zedira R001 N-(Tetramethylrhodaminyl)cadaverine 10mg
    14 Zedira F004 Fibrinogen, purified from human plasma 50mg
    15 Zedira P004 PT-Gluten 1mg
    温馨提示：不可用于临床治疗。

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