重组人信号转导与转录激活因子5B(STAT5B)

特别提示：包括重组人信号转导与转录激活因子5B(STAT5B)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人信号转导与转录激活因子5B(STAT5B)
英文名称：Recombinant Human Signal Transducer and Activator of Transcription 5B
产品规格：10μg|50μg|500μg|1mg

本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Met1-Thr321在C端含有His标签。

STAT5B质量控制：＞95%(还原性SDS-PAGE)

STAT5B制剂：液体

STAT5B保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于STAT5B：
Signal Transducer and Activator of Transcription 5b (STAT5B) is a member of the STAT family of transcription factors. They are responsible for an array of cellular activities including regulating growth, survival, differentiation, motility, and the immune response. STAT5B mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. Signal transduction and activator of transcription 5 (STAT5) is a member of the Jak/STAT signal transduction pathway and is activated by a variety of cytokines (IL22, IL6). STAT5 has two isoforms (A and B) that share 93% amino acid identity and bind the DNA consensus site TTCN3GAA. STAT5 mediates cytokine signaling by acting as a signal transducer in the cytoplasm and, upon phosphorylation, translocates to the nucleus and activates transcription of specific genes. STAT5 is involved in a wide array of biological processes ranging from regulating apoptosis to adult mammary gland proliferation, differentiation and survival.