一种选择性的竞争性的P2X7拮抗剂。A 804598 is a potent and selective P2X7 antagonist with IC50 values of 10, 9, and 11 nM for rat, mouse, and human receptors, respectively. A 804598 has been shown to potently block agonist-stimulated release of IL-1β and Yo-Pro uptake from differentiated THP-1 cells that natively express human P2X7 receptors.