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- 2025年07月12日
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安诺伦（北京）生物科技有限公司
存储温度：Store product at –20oC. For optimal storage, aliquot diluted product into smaller quantities and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
存储溶液：The peptide supplied in trifluroacetate salt as a lyophilized powder.
参考文献：1. Esler WP, et al: Stereochemical specificity of Alzheimer's disease beta-peptide assembly. Biopolymers. 1999 May;49(6):505-14. 2. Roher AE, et al: beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease. Proc Natl Acad Sci U S A. 1993 Nov 15;90 (22):10836-40.
官网链接：https://www.signalchem.com/product_details.php?id=6992
商品关键词：Amyloid beta (3-42), pyrE,A06-558V-BULK,SignalChem
简单描述：The synthetic Amyloid beta (3-42), pyrE Peptide (pyr-EFRHDSGYEV HHQKLVFFAE DVGSNKGAII GLMVGGVV IA) is derived from human amyloid beta (amino acid 3-42).
Purity: The purity was determined to be >95% by HPLC analysis. Molecular Weight: 4308.8Scientific Background: Amyloid peptides, derived from amyloid precursor protein (APP), are thought to play a role in the development of the senile plaques associated with Alzheimer’s Disease. The amyloid hypothesis presupposes that flaws in the processing of APP result in abnormally high levels of the longer, “stickier” forms of beta amyloid, known as Abeta42 and Abeta43, leading to aggregation of amyloid in the neuronal cell death and ultimately neuronal death. Mutations in the structure of Abeta40 and related peptides as well as in some of the enzymes involved in the processing of APP have been shown to alter the processing of APP. The sporadic (i.e., non-genetic) form of the disease, however, is far more common, caused by aging in concert with a number of both genetic and environmental risk factors.
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文献和实验再熬夜就真「傻」了！新研究发现，熬夜会降低大脑「排毒」效率，增加痴呆风险……
茨海默病致病蛋白（β-淀粉样蛋白）的清除作用，随着昼夜节律波动。这为昼夜节律紊乱与 β-淀粉样蛋白累积之间的联系提供了证据，也为阿尔茨海默病与睡眠周期中断之间的联系作出了解释。 图片来源：PLOS Genetics 研究内容 巨噬细胞对 Aβ42 的吞噬作用受生物钟调控 已有研究结果表明 β-淀粉样蛋白 42（Amyloid-beta 42, Aβ42）的丰度随昼夜节律波动。小胶质细胞和巨噬细胞可以吞噬 Aβ42，其中巨噬细胞的吞噬作用受到昼夜节律调节。因此，研究者假设 Aβ42 代谢
，Tiffany HL，Tumanov A，et al．Amyloid (beta) 42 activates a G-protein-coupled chemoattractant receptor，FPR-like-1．J Neurosci，2001，21:RC123．
/Amyloid__beta_-Peptide__1-42__human.html 诱导Aβ 蛋白沉积、记忆障碍、突触功能障碍和神经发生受损 Scopolamine (HY-N0296) www.medchemexpress.cn/Scopolamine.html 诱导动物认知记忆缺陷 beta-Amyloid抗体(YA6114)(HY-P86422) www.medchemexpress.cn/antibody/amyloid-%CE%B2-antibody-ya6114.html 抗 Amyloid-β
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