- ￥4786.76
- Biogems
- 美国
- 82312-25-500 μg
- 2025年07月08日
- FA, FC, Neutralization
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography.
- 克隆性：
多克隆
- 供应商：
安诺伦（北京）生物科技有限公司
- 应用范围：
FA, FC, Neutralization
- 规格：
500 μg
来源：Armenian Hamster IgG
存储溶液：Phosphate-buffered aqueous solution, ph7.2.
参考文献：Shibuya, K., Robinson, D., Zonin, F., Hartley, S. B., Macatonia, S. E., Somoza, C., ... & O’Garra, A. (1998). IL-1α and TNF-α are required for IL-12-induced development of Th1 cells producing high levels of IFN-γ in BALB/c but not C57BL/6 mice. The Journal of Immunology, 160(4), 1708-1716.Fuhlbrigge, R. C., Sheehan, K. C., Schreiber, R. D., Chaplin, D. D., & Unanue, E. R. (1988). Monoclonal antibodies to murine IL-1 alpha. Production, characterization, and inhibition of membrane-associated IL-1 activity. The Journal of Immunology, 141(8), 2643-2650.Beckerman, K. P., Rogers, H. W., Corbett, J. A., Schreiber, R. D., McDaniel, M. L., & Unanue, E. R. (1993). Release of nitric oxide during the T cell-independent pathway of macrophage activation. Its role in resistance to Listeria monocytogenes. The Journal of Immunology, 150(3), 888-895.
特异性：Mouse
官网链接：http://www.bio-gems.com/flow-cytometry/safire-functional-antibodies/anti-mouse-il-1alpha-safire.html
商品关键词：Anti-Mouse IL-1 alpha SAFIRE Purified,82312-25-500 μg,Biogems
简单描述：IL-1α is a non-secreted, proinflammatory cytokine produced in a variety of cells, including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1α and IL-1β bind to the same receptor and have similar, if not identical, biological properties. These cytokines have a broad range of activities including the stimulation of thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity, and the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. The ALF-161 monoclonal antibody reacts with the precursor, secreted and membrane-associated forms of mouse IL-1 α. The antibody is reported to be usable as the capture antibody in an ELISA assay and exhibits neutralization properties.
Clone: ALF-161
Format: SAFIRE Purified
Cell Type: Monocytes and Macrophages
官网链接: www.annoron.com
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文献和实验Intracellular Cytokine Staining Protocol
-gamma, TNF-alpha, IL-2, and IL-4, a combination of PMA (a PKC activator) and Ionomycin (a calcium ionophore) or anti-CD3 antibodies are used. To induce IL-6, IL-10 or TNF-alpha production by monocytes, stimulation of PBMC's with LPS is used.Note: Optimal
Intracellular Cytokine Staining Protocol
to produce IFN-gamma, TNF-alpha, IL-2, and IL-4, a combination of PMA (a PKC activator) and Ionomycin (a calcium ionophore) or anti-CD3 antibodies are used. To induce IL-6, IL-10 or TNF-alpha production by monocytes, stimulation of PBMC's with LPS is used
Immunohistochemisty-Fluorescence Protocol
and Secondary Reagents Biotinylated donkey anti-goat IgG (Jackson Immuno Research Lab Catalog # 705-066-147) Biotinylated goat anti-mouse IgG1 (Caltag Lab Catalog # M32115) FITC-labeled goat anti-mouse IgG1 (Caltag Lab Catalog # M32001)
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