- ￥3320
- Biogems
- AF-250-38-20µg
- 美国
- 2025年07月12日
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20µg
靶点/蛋白质：MQHYLHIRP APSDNLPLV DLIEHPDPI FDPKEKDLN ETLLRSLLG GHYDPGFMA TSPPEDRPG GGGGPAGGA EDLAELDQL LRQRPSGAM PSEIKGLEF SEGLAQGKK QRLSKKLRR KLQMWLWSQ TFCPVLYAW NDLGSRFWP RYVKVGSCF SKRSCSVPE GMVCKPSKS VHLTVLRWR CQRRGGQRC GWIPIQYPI ISECKCSC
官网链接：http://www.bio-gems.com/recombinant-proteins/animal-free-cytokines/animal-free-recombinant-murine-noggin.html
商品关键词：Animal-Free Recombinant Murine NOGGIN,AF-250-38-20µg ,Biogems
简单描述：Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF-β family and regulate their activity by inhibiting their access to signaling receptors. The interplay between TGF-β ligands and their natural antagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis. Recombinant murine Noggin is a 46.4 kDa disulfide-linked homodimer consisting of two 206 amino acid polypeptide chains. Manufactured using all non-animal reagents.
Purity: Above 95% as determined by SDS-PAGE Analysis.
Biological Activity: Determined by its ability to inhibit 5.0 ng/ml of BMP-4 induced alkaline phosphatase production by ATDC5 chondrogenic cells. The expected ED50 for this effect is 1.0-2.0 ng/ml of Noggin.
Cell Type: Stem Cells
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