- ¥1380 - 2200
- LMAI Bio
- LM-5813R
- 进口/国产
- 2026年02月04日
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- Rabbit
- Human, Mouse, Rat, Horse,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-5813R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
PRODH
- 抗体名：
脯氨酸脱氢酶抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat, Horse,
- 免疫原：
KLH conjugated synthetic peptide derived from human PRODH:141-240/600
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
100ul 200ul
| 英文名称 | PRODH |
| 中文名称 | 脯氨酸脱氢酶抗体 |
| 别 名 | HSPOX2; P53 induced gene 6 protein; PIG6; PRODH 1; PRODH 2; PRODH1; PRODH2; Proline dehydrogenase; proline dehydrogenase (oxidase) 1; proline dehydrogenase (proline oxidase); Proline oxidase, mitochondrial precursor; SCZD4; TP53I6; tumor protein p53 inducible protein 6; PROD_HUMAN. |
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 信号转导 线粒体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Horse, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 68kDa |
| 细胞定位 | 细胞浆 线粒体 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PRODH:141-240/600 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: Proline oxidase catalyzes the conversion of proline to pyrroline-5-carboxylate, or P5C during the degradation of the amino acid Proline. Defects in PRODH are the cause of hyperprolinemia type 1, a disorder characterized by elevated serum proline levels. Defective PRODH may be involved in the psychiatric and behavioral phenotypes associated with the 22q11 velocardiofacial and DiGeorge syndrome and may be associated with susceptibility to schizophrenia 4 (SCZD4). Function: Converts proline to delta-1-pyrroline-5-carboxylate. Subcellular Location: Mitochondrion matrix. Tissue Specificity: Expressed in lung, skeletal muscle and brain, to a lesser extent in heart and kidney, and weakly in liver, placenta and pancreas. DISEASE: Defects in PRODH are the cause of hyperprolinemia type 1 (HP-1) [MIM:239500]. HP-1 is a disorder characterized by elevated serum proline levels. May be involved in the psychiatric and behavioral phenotypes associated with the 22q11 velocardiofacial and DiGeorge syndrome. Defects in PRODH are associated with susceptibility to schizophrenia type 4 (SCZD4) [MIM:600850]. A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. Similarity: Belongs to the proline oxidase family. SWISS: O43272 Gene ID: 5625 Database links: Entrez Gene: 5625 Human Entrez Gene: 19125 Mouse Entrez Gene: 680409 Rat Omim: 606810 Human SwissProt: O43272 Human SwissProt: Q9WU79 Mouse Unigene: 517352 Human Unigene: 28456 Mouse Unigene: 153570 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品图片 |  Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (PRODH) Polyclonal Antibody, Unconjugated (bs-5813R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. |
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文献和实验受体BCR。 天然Ig的基本结构是一Y型的四肽链。 免疫球蛋白的基本结构示意图 典型的Is分子基本结构呈“Y”字型，由两条相同的重链(H)和两条相同的轻链(1。)借二硫键连接而成。重链和轻链近氨基端的l／4或l／2氨基酸序列的变化很大，为可变区；其他部分氨基酸序列则相对恒定，为恒定区；位于CHI与CH2之间、富含脯氦酸的区域为铰链区。 Vu和VL分别代表重链和轻链的可变区，Cu和CI。分别代表重链和轻链的恒定区。
【求助】P53的翻译后修饰都有哪些？ 怎样验证其修饰后与靶标启动子的结合活性的变化？
变异体取代能被脯氨酸激酶直接识别的脯氨酸残基后对p38磷酸化Ser-46所起的作用较弱。与此结论相一致，Ser-47变异体同野生型p53相比诱导凋亡的能力降低了5倍，此变异体转录激活两种p53凋亡靶基因（p53AIP1 ,***3）的能力减弱。p53的47位密码子多态现象在癌症发生、进展、治疗效果中可能起一定作用[19]。 p53 C-末端区域的Ser315、Ser371、Ser376 、Ser378 和Ser392的磷酸化是众所周知的，最近研究显示其他位点也可以发生磷酸
大家所熟悉，乳酸脱氢酶(LDH)有五种同工酶，它们的分子量在130，000～150，000范围内，都由四个亚基组成。LDH的亚基可以分为两型：骨骼肌型(M型)和心肌型(H型)。M、H亚基的氨基酸组成有差别，可用电泳分离。其免疫抗体无交叉反应。两种亚基以不同比例组成五种四聚体即为一组LDH同工酶LDH1(H4)、LDH2(H3M)、LDH3(H2M2)、LDH4(HM3)和LDH5(M4)。电泳时都移向正极，其速度以LDH1为最快，依次递减，以LDH5为最慢。若用12M尿素或5M盐酸胍溶液处理，M亚基和H
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