Integrin Alpha V + Beta 6整合素αV

β6抗体

价格¥1380 - 2200

品牌LMAI Bio
货号LM-5791R
产地进口/国产
更新日期2025年12月16日

应用范围WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test IF=1:100-500 （石蜡切片需做抗原修复）
宿主Rabbit
适应物种Human, Mouse, Rat,

上海联迈生物工程有限公司

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详细信息
技术资料

供应商：
上海联迈生物工程有限公司
库存：
大量
目录编号：
LM-5791R
克隆性：
多克隆
抗原来源：
Rabbit
保质期：
1年
抗体英文名：
Integrin Alpha V + Beta 6
抗体名：
整合素αVβ6抗体
宿主：
Rabbit
适应物种：
Human, Mouse, Rat,
免疫原：
KLH conjugated synthetic peptide derived from human Integrin Alpha V + Beta 6:
亚型：
IgG
形态：
Lyophilized or Liquid
应用范围：
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test IF=1:100-500 （石蜡切片需做抗原修复）
浓度：
1mg/ml
保存条件：
Store at -20 °C
规格：
100ul 200ul

Integrin Alpha V + Beta 6整合素αVβ6抗体

英文名称	Integrin Alpha V + Beta 6
中文名称	整合素αVβ6抗体
别名	CD51; Integrin alpha-V light chain; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); Integrin, alpha V; Integrin, beta 6; ITAV_HUMAN; ITGAV; ITGB6; Vitronectin receptor subunit alpha.
	Specific References (2) \| bs-5791R has been referenced in 2 publications. [IF=3.02] Li, Haixia, et al. "Scutellarin inhibits the growth and invasion of human tongue squamous carcinoma through the inhibition of matrix metalloproteinase-2 and-9 and αvβ6 integrin." International Journal of Oncology 42.5 (2013): 1674-1681. IHC-P ; Mouse. PubMed:23546449 [IF=8.31] Gao, Duo, et al."A near-infrared phthalocyanine dye-labeled agent for integrin avb6-targeted theranostics of pancreatic cancer." Biomaterials 53 (2015):229-238. IHC-P ; Human. PubMed:25890722
规格价格	100ul/1380元购买 200ul/2200元购买大包装/询价
说明书	100ul 200ul
研究领域	肿瘤心血管细胞生物免疫学信号转导生长因子和激素细胞粘附分子细胞骨架
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, Rat,
产品应用	WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	18/95/113kDa
细胞定位	细胞膜
性状	Lyophilized or Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human Integrin Alpha V + Beta 6:
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed	PubMed
产品介绍	background: Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha-v beta-6 is upregulated in cancers and during tissue remodelling but is absent from resting adult tissues. Integrin alpha-v beta-6 promotes invasion and correlates with poor survival and therefore makes a promising therapeutic target. Function: The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. Subunit: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8 subunit. Interacts with HIV-1 Tat. Alpha-V/beta-6 binds to foot-and-mouth disease virus (FMDV) VP1 protein and acts as a receptor for this virus (By similarity). Alpha-V/beta-6 binds to coxsackievirus A9 and coxsackievirus B1 capsid proteins and acts as a receptor for these viruses. Interacts with RAB25. Subcellular Location: Membrane; Single-pass type I membrane protein. Similarity: Belongs to the integrin alpha chain family. Contains 7 FG-GAP repeats. SWISS: P06756 Gene ID: 3685 Database links: Entrez Gene: 3685 Human Omim: 193210 Human SwissProt: P06756 Human Unigene: 436873 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品图片	Sample:Cerebrum (Rat) Lysate at 40 ug Primary: Anti-Integrin Alpha V+Beta 6(bs-5791R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution Predicted band size: 18/95/113kD Observed band size: 113kD Sample:Siha Cell (Human) Lysate at 40 ug Primary: Anti-Integrin Alpha V + Beta 6(bs-5791R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 18/95/113 kD Observed band size: 95 kD Sample: Kidney (Mouse) Lysate at 40 ug Primary: Anti-Integrin Alpha V + Beta 6 (bs-5791R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 18/95/113 kD Observed band size: 95 kD Blank control(blue): Hela (fixed with 2% paraformaldehyde (10 min) , then permeabilized with 90% ice-cold methanol for 30 min on ice). Primary Antibody:Rabbit Anti-Integrin Alpha V + Beta 6 antibody(bs-5791R), Dilution:1μg in 100 μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions ); Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA.