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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
TGP-210
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1049722-30-6
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥4694.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥1600.0 |
| 规格： | 5 mg | 产品价格： | ￥3600.0 |
| 规格： | 10 mg | 产品价格： | ￥6000.0 |
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Targapremir-210
CAS No. : 1049722-30-6
MCE 国际站：Targapremir-210
产品活性：Targapremir-210 (TGP-210) 是一种有效的、选择性的 miR-210 (miRNA-210, microRNA-210) 抑制剂。 Targapremir-210 以高亲和力抑制 pre-miR-210 的加工 (Kd~200 nM)。Targapremir-210 是一种点击化学试剂。它含有 Azide 基团，可以和含有 Alkyne 基团的分子发生铜催化的叠氮-炔环加成反应（CuAAc)。还可以和含有 DBCO 或 BCN 基团的分子发生菌株促进的炔-叠氮环加成反应 (SPAAC)。
研究领域：Epigenetics | Apoptosis
In Vitro: Targapremir-210 decreases mature miR-210 levels in MDA-MB-231 cells cultured under hypoxic conditions, with an IC50 of ∼200 nM.
Targapremir-210 (200 nM) induces MDA-MB-231 cells apoptosis is selective for the hypoxic environment. Targapremir-210 induces cells apoptosis under hypoxic conditions and does not induce apoptosis in MDA-MB-231 cells cultured in normoxia.
In Vivo: Targapremir-210 (100 μL of 200 nM; single i.p. injection) impedes MDA-MB-231 triple negative breast cancer (TNBC) cells proliferation in vivo. Targapremir-210 is able to reach the tumor and sustain for the entire 21-day period, and decreases tumor burden in a TNBC mouse model.
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文献和实验Chromatin immunoprecipitation protocol for Saccharomyces cerevisiae
with strain JKM179 or one of its derivatives Incubate and rotate at 180-210 rpm overnight at 30°C Dilute the overnight culture in YPLGg medium (volume should be consistent with number of timepoints, use 100ml/timepoint) Incubate
一般 断裂伸长 30%-40% 大于涤纶 18%-45% 12%-25
i-pentane(戊烷) 0.00 -- 30 -- n-pentane 0.00 0.23 36 210 Petroleum ether(石油醚) 0.01
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