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- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
221671-61-0
- 规格：
10 mM * 1 mL/1 mg/5 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥ |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥2000.0 |
| 规格： | 5 mg | 产品价格： | ￥5000.0 |
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SR 146131
CAS No. : 221671-61-0
MCE 国际站：SR 146131
产品活性：SR 146131是一种有效，有口服活性，选择性的非多肽缩胆囊素1 (cholecystokinin 1)受体激动剂。
研究领域：GPCR/G Protein | Neuronal Signaling
作用靶点：Cholecystokinin Receptor
In Vitro: SR 146131 inhibits in the binding of [125I]-BH-CCK-8S to CCK1sites on 3T3-hCCK1 cell membranes with an IC50 value of 0.56 ± 0.10 nM. At much higher concentrations, SR 146131 also inhibits the binding of radiolabeled CCK to CCK2sites in CHO-hCCK2 membranes with an IC50 of 162 ± 27 nM. SR 146131 is a potent CCK1 agonist on several intracellular events linked to CCK1 receptor activation in various cell types: on [Ca2+]i release and IP1 formation, SR 146131 appears as a full CCK1 receptor agonist in the 3T3-hCCK1 cells, but a partial CCK1receptor agonist on MAPK activation and early gene expression in this cell line. SR 146131 also acts as a partial agonist in the two neuroblastoma cell lines.
In Vivo: SR 146131 completely inhibits gastric and gallbladder emptying in mice (ED50 of 66 and 2.7 μg/kg p.o., respectively). SR 146131 dose dependently reduces food intake in fasted rats (from 0.1 mg/kg p.o.), in nonfasted rats in which food intake has been highly stimulated by the administration of neuropeptide Y (1–36) (from 0.3 mg/kg p.o.), in fasted gerbils (from 0.1 mg/kg p.o.), and in marmosets maintained on a restricted diet (from 3 mg/kg p.o.). SR 146131 (10 mg/kg p.o.) also increases the number of Fos-positive cells in the hypothalamic paraventricular nucleus of rats. Locomotor activity of mice is reduced by orally administered SR 146131 (from 0.3 mg/kg p.o.).
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文献和实验Purification of SR Protein Splicing Factors
In recent years, the SR protein family of precursor messenger RNA splicing factors has emerged as a key player in the assembly of the spliceosomal machinery onto pre-mRNA. The SR proteins are essential splicing factors and different family
清道夫受体 (scavenger receptor ， SR) 是固有免疫中一类重要的模式识别受体，分为多种类型，主要为SRA和SRB，可能还包括SRC等，其中各自又由不同的分子组成。 注：M。：单核细胞；P1t：血小板；LTA：淋巴毒素。；LDL：低密度脂蛋白。MARCO：带胶原结构的巨噬细胞受体；LOX-1：凝集素样氧化低密度脂蛋白受体；SREC：内 皮细胞表达的清道夫受体。 SPA为三聚体缠绕的糖蛋白跨膜分子，各带有5个不同的结构域。其中胶原样结构
1、目的：为使仪器正常运转，保证结果的可靠性，特制定此操作规程。2、适用范围：化验室3、责任者：化验员应严格遵照该操作规程，QC主管负责监督本规程的实施。4、定义：无5、安全注意事项：无6、操作规程6.1.准备6.1.1.控制水槽水位，使之高于溶出杯中介质的高度。6.1.2.开启溶出仪，自动取样器及打印机电源。6.1.3.排除对试验有影响振动干扰。6.1.4.调节高度：将桨或蓝的底部轻轻置于杯的底部，抬起显示面板，垫上标准垫块P或B（P为转桨法，B为转蓝法），放下显示面板，测桨或蓝的底部距杯底
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