Deltonin三角叶薯蓣皂苷,55659-75-1

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Deltonin

CAS No. : 55659-75-1

MCE 国际站：Deltonin

产品活性：Deltonin 是从盾叶薯蓣中得到的甾体皂苷，能够抑制 ERK1/2 和 AKT 的活化，具有抗肿瘤的活性。

研究领域：MAPK/ERK Pathway  |  Stem Cell/Wnt  |  PI3K/Akt/mTOR  |  Metabolic Enzyme/Protease

作用靶点：ERK  |  Akt  |  Endogenous Metabolite

结构分类：甾体类

来源：植物  |  薯蓣科  |  盾叶薯蓣

In Vitro: Deltonin inhibits ERK1/2 and AKT activation. Deltonin (0.5-8 μM) significantly inhibits the proliferation of several colon cancer cell lines including SW480, SW620, LOVO and C26, with IC₅₀s of 1.3, 1.29, 2.11 and 1.22 μM. Deltonin also causes G2-M phase arrest and induces apoptosis in C26 cells. Deltonin (0-5 μM) decreases the phosphorylation of AKT and ERK1/2 levels in MDA‑MB‑231 cells. Deltonin (0.5-8 μM) also dose-dependently inhibits the proliferation, and causes apoptosis with ROS production in MDA‑MB‑231 cells.

In Vivo: Deltonin (20 and 40 mg/kg, p.o.) reduces the tumor growth of 37.7% and 56.7%, and causes a 50-day survival rate of 60% and 50%, respectively, in mice. Deltonin also inhibits tumor angiogenesis in mice.

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