- ￥242 - 4259
- MedChemExpress(MCE)
- 美国
- HY-10426
- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
725247-18-7
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥794.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥242.0 |
| 规格： | 5 mg | 产品价格： | ￥605.0 |
| 规格： | 10 mg | 产品价格： | ￥1097.0 |
| 规格： | 50 mg | 产品价格： | ￥4259.0 |
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XCT790
CAS No. : 725247-18-7
MCE 国际站：XCT790
产品活性：XCT-790 是 ERRα 的有效选择性反向激动剂，IC50 值为 0.37 μM。XCT-790 在化疗过程中诱导癌细胞死亡。XCT-790 对 ERRγ 和雌激素受体 ERα 和 ERβ 无活性。
研究领域：Vitamin D Related/Nuclear Receptor | Autophagy
作用靶点：Estrogen Receptor/ERR | Autophagy
In Vitro: XCT-790 (0-40 μM; 48 hours and 72 hours) reduces the viability of MES-SA, MES-SA/DX5, and HepG2 cells in a dose-dependent manner.
?XCT-790 (10 μM; 24 hours and 48 hours) reduces the protein levels of ERRα in HepG2 and R-HepG2 cell lines after 24 hours and maintains these reduced levels after 48 hours.
?XCT-790 (10 μM; 48 hours) induces apoptosis in the two cell lines with HepG2 being more sensitive compared to R-HepG2.
In Vivo: XCT-790 (XCT790; 4 mg/kg; intravenous injection; every three days; for 3 weeks; BALB/c mice) significantly inhibits tumor growth and angiogenesis, and induces apoptosis without a reduction in body weight, in xenograft models.
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