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4°C, sealed storage, away from moisture
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货期：1-2天
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MedChemExpress LLC
- CAS号：
1620278-72-9
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥3300.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥1363.0 |
| 规格： | 5 mg | 产品价格： | ￥3000.0 |
| 规格： | 10 mg | 产品价格： | ￥4900.0 |
| 规格： | 25 mg | 产品价格： | ￥9600.0 |
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TLR7/8 agonist 1 dihydrochloride
CAS No. : 1620278-72-9
MCE 国际站：TLR7/8 agonist 1 dihydrochloride
产品活性：TLR7/8 agonist 1 dihydrochloride 是一种 toll 样受体 TLR7/TLR8 的双重激动剂。
作用靶点：Toll-like Receptor (TLR)
In Vitro: TLR7/8 agonist 1 (Compound 5d) shows prominent immunostimulatory activities. TLR7/8 agonist 1 serves as a convenient precursor for the covalent attachment of fluorophores without significant loss of activity. TLR7/8 agonist 1 retains TLR7-agonistic activity with an EC50 of 20 nM. TLR7/8 agonist 1 (Compound 1) shows substantially different agonistic potencies in human TLR7 (50 nM) and TLR8 (55 nM) primary screens.
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文献和实验Ligand Characterization Using Microphysiometry
the use of a Cytosensor microphysiometer for functional characterization of an agonist and antagonist to a G protein?coupled receptor, the muscarinic M1 receptor. Concentration?response profiles are used to calculate values for the EC50 of the response
15 August 2011. ^ a b Wheeler, B.; Heimberg, A.; Moy, V.; Sperling, E.; Holstein, T.; Heber, S.; Peterson, K. (2009). "The deep evolution of metazoan microRNAs". Evolution & development 11 (1): 50–68. doi:10.1111/j.1525-142X.2008.00302.x. PMID
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