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SB 202190
CAS No. : 152121-30-7
MCE 国际站：SB 202190
产品活性：SB 202190 是选择性的 p38 MAPK 抑制剂，抑制 p38α 和 p38β2 的 IC50 分别为 50 nM 和 100 nM。SB 202190 与重组人活性 p38 激酶的 ATP 袋结合，Kd 值为 38 nM。SB 202190 具有抗癌活性并可以挽救记忆障碍。
研究领域：MAPK/ERK Pathway | Autophagy | Apoptosis
作用靶点：p38 MAPK | Autophagy | Apoptosis
In Vitro: SB 202190 (0-10 μM; 0-72 hours) attenuates growth of a subgroup of CRC cell lines such as RKO, CACO2 and SW480 in a dose- and time-dependent manner.
?SB 202190 strongly inhibited colony formation and anchorage-independent growth (10 μM for 7–10 days) and elevated apoptotic cell death (10 μM for 72 h) in this same subset of CRC lines (RKO, CACO2 and SW480).
?In RKO, CACO2 and SW480 cells, SB202190 (10 μM; 2 hours) abrogates phosphorylation of S6K1(T389) and S6(S235/236), but not AKT(S473), indicating that p38i selectively blocks mTORC1 signaling.
In Vivo: SB 202190 (5 mg/kg; intraperitoneal injection; daily for 10-12 days) shows inhibition of tumor cell survival and tumor growth.
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文献和实验merck的代理商，要买的话可以跟我联系 selleckchem01 SB 202190：SB202190 blocked p38 half maximally at 30 nM. Concentrations as high as 30,000 nM did not inhibit ERK and JNK activity.作用效果如下： SB 203580：SB 203580 is a potent inhibitor of LPS
世霸总批发 SB1A01 SB1A01S SB1A02 SB1A02S SB1A03 SB1A03S SB1A01E SB1A01ES
徐州往事 我想做大鼠的p38MAPK的试验，需要用到SB203580干预，请问在大鼠中，SB203580的给药途径和剂量，最好能提供相关文献。谢谢 piaopiao5556 彼此彼此 ，我也做这个的 各个文献用量不一样，尤其关于大鼠的很少，看到一篇要用到50mg/kg。实验1小时前给药，哪来这么多钱啊？ 624980241 侧脑室 给药的量是 多少啊 ？ ldmin
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