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- 2025年12月05日
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- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
842148-40-7
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥3850.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥1591.0 |
| 规格： | 5 mg | 产品价格： | ￥3500.0 |
| 规格： | 10 mg | 产品价格： | ￥4950.0 |
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AKT Kinase Inhibitor
CAS No. : 842148-40-7
MCE 国际站：AKT Kinase Inhibitor
产品活性：AKT Kinase Inhibitor 是一种具有抗肿瘤活性的 Akt 抑制剂。
研究领域：PI3K/Akt/mTOR
作用靶点：Akt
In Vitro: The effect of selective inhibition of Akt in proliferating cells expressing Trop-2 is studied. Akt inhibition, either by silencing or with specific drugs, induces a marked decrease in cell proliferation in cells expressing Trop-2, in a dose-dependent fashion.
In Vivo: Trop-2 expressing tumors subcutaneously injected in animal models show a striking reduction of growth following treatment with specific drugs that inhibit Akt activity. Therefore Akt has a central functional role in mediating the Trop-2-dependent growth stimulus.
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文献和实验Assaying AKT/Protein Kinase B Activity
Akt/protein kinase B (PKB) is a serine/threonine kinase that mediates many of the anabolic actions of insulin ( 1 ), as well as the growth-promoting and/or antiapoptotic effects of other growth factors, cytokines
Assessment of PI-3 Kinase and Akt in Ischemic Heart Diseases in Diabetes
targets in these conditions. Phosphatidylinositol (PI)-3 kinase (PI3K) and Akt are key signaling molecules in insulin and insulin-like growth factor-1 (IGF-1), which induce multiple biological effects in the heart such as cell survival and hypertrophy
相关专题 Akt1, also known as "Akt" or protein kinase B (PKB). Its signalling pathway is as follows: 1. Binds to phospholipids in the membrane 2. Phosphorylation by PDK1 and PDK2 3. Lipid phosphatases
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