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SCH 42495 racemate
CAS No. : 145841-10-7
MCE 国际站：SCH 42495 racemate
产品活性：SCH 42495 racemate 是 Sch-42495 的外消旋体。SCH 42495 是一种具有口服活性的中性金属内肽酶 (NEP) 抑制剂，具有抗高血压活性。SCH 42495 是 SCH 42354 的口服活性前体。
研究领域：Metabolic Enzyme/Protease
作用靶点：Neprilysin
In Vitro: SCH 42495 selectively inhibits hydrolysis of leu-enkephalin and ANF (IC50 of 8.3 and 10.0 nM, respectively) in vitro.
In Vivo: SCH 42495 (30 mg/kg; oral gavage; twice daily) causes a significant reduction in the pulmonary vascular remodelling and ventricular hypertrophy in hypoxic rats after 10 days.
Treatment with SCH 42495 (30 mg/kg; oral gavage; twice daily) leads to a decrease in cardiovascular remodelling secondary to chronic hypoxia in rats.
SCH 42495 (oral doses of 1, 3, or 10 mg/kg) produces significant reductions in blood pressure in DOCA-N a hypertensive rats of 22±6, 43±7, and 62±12 mm Hg, respectively.
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文献和实验疟原虫 Malaria Parasites(Plasmodium)
. Department of Health, Education and Welfare, Bethesda, 1971.Fig. 1: Normal red cell; Figs. 2-18: Trophozoites (among these, Figs. 2-10 correspond to ring-stage trophozoites); Figs. 19-26: Schizonts (Fig. 26 is a ruptured schizont); Figs. 27, 28
Dopamine Receptor Binding and Quantitative Autoradiographic Study
and extensively used to characterize the classical dopamine receptor subtypes. These radioligands include the D1 -selective ligands [3 H]SCH 23390 and [125 I]SCH 23982. D2 receptor-selective ligands include the antagonists [3 H]spiperone, [3 H]YM 09151-2, and [125
Fluorescence Correlation Spectroscopy (FCS)-Based Characterisation of Aptamer Ligand Interaction
target and its corresponding RNA aptamer selected via systematic evolution of ligands by exponential enrichment (SELEX) (Sch�rer, et al. (2001) Biol. Chem . 382 , 47948). Here, an FCS titration experiment is described in detail, where the binding
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