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- 2025年12月05日
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- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
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货期：1-2天
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MedChemExpress LLC
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10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥2145.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥880.0 |
| 规格： | 5 mg | 产品价格： | ￥1950.0 |
| 规格： | 10 mg | 产品价格： | ￥2800.0 |
| 规格： | 25 mg | 产品价格： | ￥4500.0 |
| 规格： | 50 mg | 产品价格： | ￥5980.0 |
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Mutant IDH1-IN-1
CAS No. : 1355326-21-4
MCE 国际站：Mutant IDH1-IN-1
产品活性：Mutant IDH1-IN-1是 IDH1 突变体的选择性抑制剂，对突变体IDH1 R132C/R132C，IDH1 R132H/R132H，IDH1 R132H/WT和野生型IDH1的 IC50 值分别为4, 42, 80 和 143 nM。
研究领域：Metabolic Enzyme/Protease
作用靶点：Isocitrate Dehydrogenase (IDH)
相关产品：Bioactive Compound Library Plus | Metabolism/Protease Compound Library | Anti-Cancer Compound Library | Glutamine Metabolism Compound Library | Anti-Cancer Metabolism Compound Library | Mitochondria-Targeted Compound Library | Glucose Metabolism Compound Library | TCA Cycle Compound Library | Highly Selective Inhibitors Library | Ivosidenib | Enasidenib | Vorasidenib | AGI-6780 | GSK864 | AGI-5198 | BAY-1436032 | IDH-305 | Olutasidenib | DS-1001b | GSK321 | (R,R)-GSK321 | IDH1 Inhibitor 2 | Mutant IDH1 inhibitor | IDH889 | IDH1 Inhibitor 7 | IDH1 Inhibitor 1 | Mutant IDH1-IN-2 | AGI-12026 | Alternaphenol B2 | IDH-C227 | IDH1 Inhibitor 3 | IDH1 Inhibitor 5
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文献和实验Rats have been extensively used to explore the brain mechanisms underlying psychiatric disorders. However, due to a lack of sufficient tools for the generation of knockout or mutant rats, there has been a general lag in the understanding
Nature 重磅：新发脑胶质瘤疫苗初见成效，瞄准肿瘤「阿喀琉斯之踵」
，发挥抗肿瘤效应。该成果以 A vaccine targeting mutant IDH1 in newly diagnosed glioma 为题发表在最新的 Nature 上 [2]。 图片来源：Nature 研究内容：这是一项靶向 IDH1R132H 的多肽疫苗治疗 III-IV 级（WHO 分级）胶质瘤的安全性、耐受性和免疫原性的多中心 I 期临床研究（NCT02454634）。研究人员筛选了 44 名患者，其中 32 名患者入组参与了临床试验并接受了 IDH-vac 治疗。在这 32 名
The mouse is now firmly established as the model organism of choice for scientists studying mammalian biology and human disease. Consequently, a plethora of novel, genetically altered (GA) mouse lines have been created. In addition
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