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- 2025年12月05日
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- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥742.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥675.0 |
| 规格： | 10 mg | 产品价格： | ￥1080.0 |
| 规格： | 25 mg | 产品价格： | ￥2100.0 |
| 规格： | 50 mg | 产品价格： | ￥3255.0 |
| 规格： | 100 mg | 产品价格： | ￥4558.0 |
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KRN-633
CAS No. : 286370-15-8
MCE 国际站：KRN-633
产品活性：KRN-633 是 VEGFR 的有效抑制剂，对VEGFR1，VEGFR2 和 VEGFR3的IC50 值分别为170，160和125 nM。
研究领域：Protein Tyrosine Kinase/RTK
作用靶点：VEGFR
In Vitro: KRN-633 inhibits tyrosine phosphorylation of VEGFR-1, VEGFR2, c-Kit, and PDGFR-β (IC50=11.7, 1.16, 8.01, 130 nM) in human umbilical vein endothelial cells. KRN-633 also inhibits the VEGF-driven proliferation of HUVECs (IC50=14.9 nM). KRN-633 suppresses capillary tube formation of endothelial cells.
In Vivo: KRN-633 inhibits tumor growth in several tumor xenograft models with diverse tissue origins, including lung, colon, and prostate, in athymic mice and rats. KRN-633 also causes the regression of some well-established tumors and those that have regrown after the cessation of treatment. KRN-633 is well tolerated and has no significant effects on body weight or the general health of the animals. Histologic analysis of tumor xenografts treated with KRN-633 reveals a reduction in the number of endothelial cells in non-necrotic areas and a decrease in vascular permeability.
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文献和实验MitoProbe DiIC1 Mitochondrial Membrane Potential Protocol
of DiIC1(5) are 638 nm and 658 nm, respectively. Cells labeled with DiIC1(5) can be analyzed by flow cytometry using 633 nm excitation and far red emission, and by fluorescence microscopy using standard filters for Alexa Fluor® 633 dye. 实验
0:00 荧光标记果蝇心脏组织0 0:10 内容简介10 0:21 内容订阅21 1:50 准备工作、剥离心脏110 6:33 成年果蝇心脏装片393 8:15 果蝇幼虫心脏装片495 9:35 荧光标记果蝇心脏组织结果575 10:33 结论633 荧光标记果蝇心脏组织本视频来源于网络，如有异议请联系我们，我们将在5个工作日内作出处理。
MCH Pg 20.633±0.938 324 15.0-29.0
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