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- MedChemExpress(MCE)
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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
942947-93-5
- 规格：
1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 1 mg | 产品价格： | ￥400.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥924.0 |
| 规格： | 10 mg | 产品价格： | ￥1663.0 |
| 规格： | 25 mg | 产品价格： | ￥2813.0 |
| 规格： | 50 mg | 产品价格： | ￥4188.0 |
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CCT129202
CAS No. : 942947-93-5
MCE 国际站：CCT129202
产品活性：CCT129202 是极光激酶 (aurora) 抑制剂，对极光激酶 A，B，C 的 IC50 值分别为42，198 和227 nM。
研究领域：Cell Cycle/DNA Damage | Epigenetics
作用靶点：Aurora Kinase
In Vitro: CCT129202 causes the accumulation of human tumor cells with z4N DNA content, leading to apoptosis. CCT129202 is found to induce apoptosis with GI50 values that ranges between 0.08 and 1.7 μM. CCT120202-treated human tumor cells shows a delay in mitosis, abrogation of nocodazole-induced mitotic arrest, and spindle defects. CCT129202 Causes p21Up-regulation, Rb Hypophosphorylation, and H2F-DependentTK1Down-regulation.
In Vivo: Growth of HCT116 xenografts in nude mice is inhibited after i.p. administration of CCT129202. p21, the cyclin-dependent kinase inhibitor, is induced by CCT129202. Up-regulation of p21 by CCT129202 in HCT116 cells led to Rb hypophosphorylation and E2F inhibition, contributing to a decrease in thymidine kinase 1 transcription.
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