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PKG drug G1
CAS No. : 374703-78-3
MCE 国际站：PKG drug G1
产品活性：PKG drug G1 靶向作用于 PKG Iα。PKG drug G1 通过 C42 PKGIα 非依赖性机制有助于血管舒张和血压降低。
研究领域：Others
作用靶点：Others
In Vivo: PKG drug G1 induces vasodilation of isolated resistance blood vessels and blood pressure lowering in a mouse model of angiotensin II–induced hypertension. PKG drug G1 efficiently relaxes WT but not knockin (KI) vessels, which is then assessed in a murine model of hypertension. PKG drug G1 lowers blood pressure in hypertensive WT, but not KI, mice in vivo. PKG drug G1 is tested in vivo in healthy mice implanted with telemetric devices that allow blood pressure and heart rate to be constantly monitored. PKG drug G1 or vehicle control is administrated by intraperitoneal injection, and the acute impact on hemodynamics assessed. PKG drug G1 administered at 7.4 mg/kg does not decrease blood pressure, but there is a concomitant reflex tachycardia. When this is repeated using 14.8 mg/kg dose of PKG drug G1, again blood pressure is not altered-but this higher dose induces a potentiated increase in heart rate.
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生物化学与分子生物学实验技术．北京：高等教育出版社，2001 [77] 汪家政， 范明.蛋白质技术手册.北京：科学出版社，2000 [78] Sun Y,Cheng RX,Feng DY,et al.Effect of HCV NS3 on proliferation and phosphorylation of MAPK in human hepat℃ytes.Shijie Huaren Xiaohua Zazhi,2003,11(2) [79] Wan Y, Zheng YZ
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