SB 239063,193551-21-2

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SB 239063

CAS No. : 193551-21-2

MCE 国际站：SB 239063

产品活性：SB 239063 是一种有效、选择性、可口服的 p38 MAPK 抑制剂，对重组纯化的人 p38α 的 IC₅₀ 值为 44 nM，对 p38α 和 p38β 的活性等效，但对 p38γ 或 p38δ 无所用。具有抗哮喘作用，还被用于增强因衰老或疾病受损的记忆，如阿尔茨海默病。

研究领域：MAPK/ERK Pathway  |  Autophagy

作用靶点：p38 MAPK  |  Autophagy

In Vitro: SB 239063 (0.1–10 μM ; 29 hours, 47 hours) increases apoptosis of eosinophils in a dose-related in the presence of 10 pM IL-5 at every time point from 21 hours onwards.
?SB 239063 potently inhibits IL-1 and TNF- a production in LPS-stimulated human peripheral blood monocytes with IC₅₀ values of 120 nM and 350 nM, respectively.

In Vivo: SB 239063 (12 mg/kg; p.o.; 1 hour before and 4 hours after OA challenge; b.i.d. for 3 days) significantly inhibits the resultant antigen-induced airway eosinophilia.
?SB 239063 (12 mg/kg; p.o.) almost abolishes ovalbumin (OA)-induced airway eosinophilia (~ 93% inhibition) by inhalation.
?SB 239063 is a potent inhibitor of LPS-induced TNF-alpha production in the mouse peritoneal cavity with an EC₅₀ of 5.8 mg/kg (2.8–10.3; 95% CL).

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