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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
864082-47-3
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥618.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥288.0 |
| 规格： | 5 mg | 产品价格： | ￥650.0 |
| 规格： | 10 mg | 产品价格： | ￥1000.0 |
| 规格： | 25 mg | 产品价格： | ￥1720.0 |
| 规格： | 50 mg | 产品价格： | ￥2600.0 |
| 规格： | 100 mg | 产品价格： | ￥4500.0 |
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GSK429286A
CAS No. : 864082-47-3
MCE 国际站：GSK429286A
产品活性：GSK429286A是选择性的 ROCK1 抑制剂，IC50 值为14 nM。
研究领域：Cell Cycle/DNA Damage | Stem Cell/Wnt | Cytoskeleton | TGF-beta/Smad
作用靶点：ROCK
In Vitro: GSK429286A at 1 μM reduces ROCK2 activity over 20-fold, under conditions in which the only other kinase tested that is significantly inhibited is MSK1 whose activity is reduced ~5-fold. GSK429286A is a more selective ROCK2 inhibitor than the widely utilized ROCK inhibitor Y-27632 as assessed on kinase-specificity panel, and does not significantly inhibit LRRK2 even at doses as high as 30 μM (500-fold higher than IC50 of inhibition of ROCK2). GSK429286A slightly inhibits RSK and p70S6K with IC50 of 0.78 μM and 1.94 μM, respectively. GSK429286A significantly inhibits rat aortic ring dilation with IC50 of 190 nM.
In Vivo: GSK429286A has 61% oral bioavailability in male Sprague-Dawley rats. Oral administration of GSK429286A at single doses of 3-30 mg/kg dramatically reduces mean arterial pressure in the spontaneously hypertensive rats (SHRs) in a dose-dependent manner, with a maximum decrease of 50 mmHg after approximately 2 hours treatment at dose of 30 mg/kg.
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文献和实验v468. chapter 4 WNT 细胞通路 检测细胞GSK3活性与表达水平
organelles. Two isoforms areencoded by separate genes; GSK3b (chromosome 19q13.2)encodes a protein of 51 kDa, while GSK3b (chromosome 3q13.3)encodes a protein of 47 kDa (1 – 3) . The difference in size is dueto a glycine-rich N-terminal insertion in GSK
DNA extraction from Mutation Detection Enhancement (MDE) Gel Stained with Silver Nitrate
'); these amplified a 146-bp fragment of exon 3 of the CTNNB1 gene, encompassing the sequence for GSK-3¦Â phosphorylation. The PCR conditions consisted of 1 cycle at 95˚C for 5 min; 40 cycles at 95˚C for30 sec, 55˚C for 45 sec, and 72˚C for 75 sec; at a final
DNA extraction from Mutation Detection Enhancement (MDE) Gel
DNA polymerase (Cinagen, Tehran, IRAN). The primers used were 3-A (5'-TAGTCACTGGCAACAGTCTT-3') and 3-B (5'-AAAATCCCTGTTCCCACTCATAC¨C3'); these amplified a 146-bp fragment of exon 3 of the CTNNB1 gene, encompassing the sequence for GSK-3¦Â
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